Summary of Study ST002320
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001486. The data can be accessed directly via it's Project DOI: 10.21228/M8N999 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002320 |
Study Title | Untargeted Fecal Metabolomic Analyses Across an Industrialization Gradient Reveal Shared Metabolites and Impact of Industrialization on Fecal Microbiome-Metabolome Interactions |
Study Summary | The metabolome is a central determinant of human phenotypes and includes the plethora of small molecules produced by host and microbiome, or taken up from exogenous sources. However, studies of the metabolome have so far focused predominantly on urban, industrialized populations. Through an untargeted metabolomic analysis of 90 fecal samples from human individuals from Africa and the Americas—the birthplace and the last continental expansion of our species, respectively—we characterized a shared human fecal metabolome. The majority of detected metabolite features were ubiquitous across populations, despite any geographic, dietary, or behavioral differences. Such shared metabolite features included hyocholic acid and cholesterol. However, any characterization of the shared human fecal metabolome is insufficient without exploring the influence of industrialization. Here, we show chemical differences along an industrialization gradient, where the degree of industrialization correlates with metabolomic changes. We identified differential metabolite features like amino acid-conjugated bile acids and urobilin as major metabolic correlates of these behavioral shifts. Additionally, co-analyses with over 5,000 publicly available human fecal samples and co-occurrence probability analyses with the gut microbiome highlight connections between the human fecal metabolome and gut microbiome. Our results indicate that industrialization significantly influences the human fecal metabolome, but diverse human lifestyles and behavior still maintain a shared human fecal metabolome. This study represents the first characterization of the shared human fecal metabolome through untargeted analyses of populations along an industrialization gradient. |
Institute | University of Oklahoma |
Last Name | Haffner |
First Name | Jacob |
Address | 101 David L. Boren Blvd, Norman, OK, 73019 |
jacob.haffner@ou.edu | |
Phone | 405-325-7381 |
Submit Date | 2022-10-07 |
Num Groups | 6 |
Total Subjects | 90 |
Num Males | 29 |
Num Females | 47 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzXML |
Analysis Type Detail | LC-MS |
Release Date | 2022-10-25 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Population | Industrialization_Category | Sex | Age | Time_Kept_on_Ice_before_Frozen |
---|---|---|---|---|---|---|
SA227282 | TM09_02 | Boulkiemd� | Rural Traditional | F | 32 | Within 1 day |
SA227283 | TM17_02 | Boulkiemd� | Rural Traditional | F | 35 | Within 1 day |
SA227284 | TM20_03 | Boulkiemd� | Rural Traditional | F | 37 | Within 1 day |
SA227285 | TM25_03 | Boulkiemd� | Rural Traditional | F | 38 | Within 1 day |
SA227286 | TM11_04 | Boulkiemd� | Rural Traditional | F | 40 | Within 1 day |
SA227287 | TM23_02 | Boulkiemd� | Rural Traditional | F | 51 | Within 1 day |
SA227288 | TM22_03 | Boulkiemd� | Rural Traditional | M | 29 | Within 1 day |
SA227289 | TM13_01 | Boulkiemd� | Rural Traditional | M | 53 | Within 1 day |
SA227290 | TM10_01 | Boulkiemd� | Rural Traditional | M | 55 | Within 1 day |
SA227291 | TM01_01 | Boulkiemd� | Rural Traditional | M | 55 | Within 1 day |
SA227292 | TM29_01 | Boulkiemd� | Rural Traditional | M | 73 | Within 1 day |
SA227293 | GU2 | Guayabo | Rural Industrial | F | 19 | Within 4 days |
SA227294 | GU19 | Guayabo | Rural Industrial | F | 24 | Within 4 days |
SA227295 | GU4 | Guayabo | Rural Industrial | F | 40 | Within 4 days |
SA227296 | GU13 | Guayabo | Rural Industrial | F | 41 | Within 4 days |
SA227297 | GU17 | Guayabo | Rural Industrial | F | 51 | Within 4 days |
SA227298 | GU1 | Guayabo | Rural Industrial | F | 52 | Within 4 days |
SA227299 | GU10 | Guayabo | Rural Industrial | F | 58 | Within 4 days |
SA227300 | GU20 | Guayabo | Rural Industrial | F | 63 | Within 4 days |
SA227301 | GU12 | Guayabo | Rural Industrial | NA | 16 | Within 4 days |
SA227302 | GU6 | Guayabo | Rural Industrial | NA | 6 | Within 4 days |
SA227303 | GU11 | Guayabo | Rural Industrial | NA | 7 | Within 4 days |
SA227304 | GU7 | Guayabo | Rural Industrial | NA | 9 | Within 4 days |
SA227305 | SM02 | Matses | Isolated Traditional | F | 25 | Within 4 days |
SA227306 | SM39 | Matses | Isolated Traditional | F | 40 | Within 4 days |
SA227307 | SM29 | Matses | Isolated Traditional | F | 50 | Within 4 days |
SA227308 | SM28 | Matses | Isolated Traditional | F | 52 | Within 4 days |
SA227309 | SM33 | Matses | Isolated Traditional | F | 5 | Within 4 days |
SA227310 | SM10 | Matses | Isolated Traditional | F | 6 | Within 4 days |
SA227311 | SM03 | Matses | Isolated Traditional | M | 10 | Within 4 days |
SA227312 | SM37 | Matses | Isolated Traditional | M | 12 | Within 4 days |
SA227313 | SM01 | Matses | Isolated Traditional | M | 30 | Within 4 days |
SA227314 | SM41 | Matses | Isolated Traditional | M | 6 | Within 4 days |
SA227315 | SM23 | Matses | Isolated Traditional | M | 7 | Within 4 days |
SA227316 | NO23 | Norman | Urban Industrial | F | 26 | Within 1 day |
SA227317 | NO12 | Norman | Urban Industrial | F | 27 | Within 1 day |
SA227318 | NO08 | Norman | Urban Industrial | F | 32 | Within 1 day |
SA227319 | NO07 | Norman | Urban Industrial | F | 32 | Within 1 day |
SA227320 | NO19 | Norman | Urban Industrial | F | 32 | Within 1 day |
SA227321 | NO09 | Norman | Urban Industrial | F | 34 | Within 1 day |
SA227322 | NO02 | Norman | Urban Industrial | F | 37 | Within 1 day |
SA227323 | NO21 | Norman | Urban Industrial | M | 23 | Within 1 day |
SA227324 | NO01 | Norman | Urban Industrial | M | 23 | Within 1 day |
SA227325 | NO04 | Norman | Urban Industrial | M | 26 | Within 1 day |
SA227326 | NO20 | Norman | Urban Industrial | M | 26 | Within 1 day |
SA227327 | NO11 | Norman | Urban Industrial | M | 26 | Within 1 day |
SA227328 | NO22 | Norman | Urban Industrial | M | 26 | Within 1 day |
SA227329 | NO06 | Norman | Urban Industrial | M | 28 | Within 1 day |
SA227330 | NO05 | Norman | Urban Industrial | M | 28 | Within 1 day |
SA227331 | NO13 | Norman | Urban Industrial | M | 35 | Within 1 day |
SA227332 | NO03 | Norman | Urban Industrial | M | 40 | Within 1 day |
SA227333 | NO10 | Norman | Urban Industrial | M | 41 | Within 1 day |
SA227334 | 6TM | Tambo de Mora | Rural Industrial | F | 31 | Within 4 days |
SA227335 | 26TM | Tambo de Mora | Rural Industrial | F | 36 | Within 4 days |
SA227336 | 16TM | Tambo de Mora | Rural Industrial | F | 38 | Within 4 days |
SA227337 | 4TM | Tambo de Mora | Rural Industrial | F | 40 | Within 4 days |
SA227338 | 2TM | Tambo de Mora | Rural Industrial | F | 40 | Within 4 days |
SA227339 | 1TM | Tambo de Mora | Rural Industrial | F | 61 | Within 4 days |
SA227340 | 14TM | Tambo de Mora | Rural Industrial | F | 77 | Within 4 days |
SA227341 | 11TM | Tambo de Mora | Rural Industrial | M | 39 | Within 4 days |
SA227342 | 18TM | Tambo de Mora | Rural Industrial | NA | 13 | Within 4 days |
SA227343 | 27TM | Tambo de Mora | Rural Industrial | NA | 13 | Within 4 days |
SA227344 | 31TM | Tambo de Mora | Rural Industrial | NA | 28 | Within 4 days |
SA227345 | 3TM | Tambo de Mora | Rural Industrial | NA | 5 | Within 4 days |
SA227346 | 17TM | Tambo de Mora | Rural Industrial | NA | 7 | Within 4 days |
SA227347 | 10TM | Tambo de Mora | Rural Industrial | NA | 8 | Within 4 days |
SA227348 | HCO61 | Tunapuco | Rural Traditional | F | 20 | Within 4 days |
SA227349 | HCO67 | Tunapuco | Rural Traditional | F | 26 | Within 4 days |
SA227350 | HCO14 | Tunapuco | Rural Traditional | F | 34 | Within 4 days |
SA227351 | HCO12 | Tunapuco | Rural Traditional | F | 35 | Within 4 days |
SA227352 | HCO01 | Tunapuco | Rural Traditional | F | 36 | Within 4 days |
SA227353 | HCO74 | Tunapuco | Rural Traditional | F | 36 | Within 4 days |
SA227354 | HCO70 | Tunapuco | Rural Traditional | F | 40 | Within 4 days |
SA227355 | HCO53 | Tunapuco | Rural Traditional | F | 44 | Within 4 days |
SA227356 | HCO72 | Tunapuco | Rural Traditional | F | 5 | Within 4 days |
SA227357 | HCO15 | Tunapuco | Rural Traditional | F | 63 | Within 4 days |
SA227358 | HCO63 | Tunapuco | Rural Traditional | F | 6 | Within 4 days |
SA227359 | HCO17 | Tunapuco | Rural Traditional | F | 7 | Within 4 days |
SA227360 | HCO13 | Tunapuco | Rural Traditional | F | 9 | Within 4 days |
SA227361 | HCO10 | Tunapuco | Rural Traditional | M | 10 | Within 4 days |
SA227362 | HCO21 | Tunapuco | Rural Traditional | M | 10 | Within 4 days |
SA227363 | HCO66 | Tunapuco | Rural Traditional | M | 11 | Within 4 days |
SA227364 | HCO18 | Tunapuco | Rural Traditional | M | 11 | Within 4 days |
SA227365 | HCO11 | Tunapuco | Rural Traditional | M | 36 | Within 4 days |
SA227366 | HCO03 | Tunapuco | Rural Traditional | M | 6 | Within 4 days |
SA227367 | HCO68 | Tunapuco | Rural Traditional | M | 7 | Within 4 days |
SA227368 | HCO16 | Tunapuco | Rural Traditional | NA | 11 | Within 4 days |
SA227369 | HCO09 | Tunapuco | Rural Traditional | NA | 13 | Within 4 days |
SA227370 | HCO41 | Tunapuco | Rural Traditional | NA | 54 | Within 4 days |
SA227371 | HCO69 | Tunapuco | Rural Traditional | NA | 9 | Within 4 days |
Showing results 1 to 90 of 90 |