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MB Sample ID: SA095431
| Local Sample ID: | 10050_T0 |
| Subject ID: | SU001393 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Age Or Age Range: | 18-90+ |
| Gender: | Male and female |
| Human Race: | White, Black, Asian, Other |
| Human Inclusion Criteria: | Criteria for inclusion were as follows: (1) patients 18 years or older with confirmed or presumed infection; (2) the presence of 2 or more systemic inflammatory response criteria; (3) enrollment within 24 hours of recognition of septic shock with initiation of a standardized sepsis treatment pathway; (4) the use of high-dose vasopressors (norepinephrine bitartrate >0.05 μg/kg/min, dopamine hydrochloride >10 μg/kg/min, phenylephrine hydrochloride >0.4 μg/kg/min, epinephrine >0.05 μg/kg/min, or any vasopressin dose) to treat shock for at least 4 hours at the time of enrollment; (5) cumulative SOFA score of at least 6; (6) and blood lactate level exceeding 18 mg/dL |
| Human Exclusion Criteria: | . Patients were excluded if they were pregnant or breastfeeding or had any of the following characteristics: primary diagnosis other than sepsis, an established do-not-resuscitate status or advance directive restricting aggressive care, any history of seizures, known inborn error of metabolism, anticipated surgery that would interfere with a 12-hour infusion, active participation in another interventional trial, cardiopulmonary resuscitation before enrollment, known allergy to levocarnitine, active warfarin treatment, or severe immunocompromised state |
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Collection:
| Collection ID: | CO001388 |
| Collection Summary: | Serum collected via existing intravenous or arterial catheter |
| Collection Protocol Comments: | T0: collected before carnitine or placebo administration, T24: collected 24h after administration of L-carnitine or placebo (±4h), T48: collected 48h after administration of L-carnitine or placebo (±4h) |
| Sample Type: | Blood (serum) |
| Collection Method: | via existing intravenous or arterial catheter |
| Collection Frequency: | 1/timepoint, 5 collections/72h |
| Storage Conditions: | -80℃ |
| Collection Vials: | SST: Becton-Dickinson 10mL vacutainer Serum Separator tubes |
| Storage Vials: | Sterile 1mL cryovials |
