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MB Sample ID: SA095488
| Local Sample ID: | 20003_T0 |
| Subject ID: | SU001393 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Age Or Age Range: | 18-90+ |
| Gender: | Male and female |
| Human Race: | White, Black, Asian, Other |
| Human Inclusion Criteria: | Criteria for inclusion were as follows: (1) patients 18 years or older with confirmed or presumed infection; (2) the presence of 2 or more systemic inflammatory response criteria; (3) enrollment within 24 hours of recognition of septic shock with initiation of a standardized sepsis treatment pathway; (4) the use of high-dose vasopressors (norepinephrine bitartrate >0.05 μg/kg/min, dopamine hydrochloride >10 μg/kg/min, phenylephrine hydrochloride >0.4 μg/kg/min, epinephrine >0.05 μg/kg/min, or any vasopressin dose) to treat shock for at least 4 hours at the time of enrollment; (5) cumulative SOFA score of at least 6; (6) and blood lactate level exceeding 18 mg/dL |
| Human Exclusion Criteria: | . Patients were excluded if they were pregnant or breastfeeding or had any of the following characteristics: primary diagnosis other than sepsis, an established do-not-resuscitate status or advance directive restricting aggressive care, any history of seizures, known inborn error of metabolism, anticipated surgery that would interfere with a 12-hour infusion, active participation in another interventional trial, cardiopulmonary resuscitation before enrollment, known allergy to levocarnitine, active warfarin treatment, or severe immunocompromised state |
Select appropriate tab below to view additional metadata details:
NMR:
| NMR ID: | NM000161 |
| Analysis ID: | AN002195 |
| Instrument Name: | Varian 11.74T |
| Instrument Type: | FT-NMR |
| NMR Experiment Type: | 1D-1H |
| NMR Comments: | Arrayed for water saturation frequency and 90deg. pulse width for each sample. Varian (now Agilent, Inc., Santa Clara, CA) 11.74 Tesla (500 MHz) NMR spectrometer |
| Spectrometer Frequency: | 500 MHz |
| NMR Probe: | 5-mm Agilent “One-probe |
| NMR Solvent: | D20 |
| NMR Tube Size: | 5mm |
| Shimming Method: | Auto shim (gradient shimming) |
| Pulse Sequence: | 1 H,1 H-NOESY (commonly referred to as a 1D-NOESY or METNOESY) |
| Water Suppression: | saturation at 80 Hz induced field strength |
| Pulse Width: | ~5.5ms, arrayed for in each sample |
| Temperature: | 25 |
| Number Of Scans: | 32 |
