Return to study ST001319 main page
MB Sample ID: SA095305
| Local Sample ID: | 110003_T0 |
| Subject ID: | SU001393 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Age Or Age Range: | 18-90+ |
| Gender: | Male and female |
| Human Race: | White, Black, Asian, Other |
| Human Inclusion Criteria: | Criteria for inclusion were as follows: (1) patients 18 years or older with confirmed or presumed infection; (2) the presence of 2 or more systemic inflammatory response criteria; (3) enrollment within 24 hours of recognition of septic shock with initiation of a standardized sepsis treatment pathway; (4) the use of high-dose vasopressors (norepinephrine bitartrate >0.05 μg/kg/min, dopamine hydrochloride >10 μg/kg/min, phenylephrine hydrochloride >0.4 μg/kg/min, epinephrine >0.05 μg/kg/min, or any vasopressin dose) to treat shock for at least 4 hours at the time of enrollment; (5) cumulative SOFA score of at least 6; (6) and blood lactate level exceeding 18 mg/dL |
| Human Exclusion Criteria: | . Patients were excluded if they were pregnant or breastfeeding or had any of the following characteristics: primary diagnosis other than sepsis, an established do-not-resuscitate status or advance directive restricting aggressive care, any history of seizures, known inborn error of metabolism, anticipated surgery that would interfere with a 12-hour infusion, active participation in another interventional trial, cardiopulmonary resuscitation before enrollment, known allergy to levocarnitine, active warfarin treatment, or severe immunocompromised state |
Select appropriate tab below to view additional metadata details:
Sample Preparation:
| Sampleprep ID: | SP001401 |
| Sampleprep Summary: | Methanol precipitation, ultrafiltration |
| Sampleprep Protocol ID: | Methanol precipitation, Ultrafiltration |
| Sampleprep Protocol Filename: | 235.01-Serum_MeOH_Precip_and_Resuspension, Expt._235.1_Filtration_of_CaPS_RACE_Serums |
| Processing Method: | Methanol precipitation, dried by lyophilization, ultrafiltered |
| Processing Storage Conditions: | On ice |
| Extraction Method: | Methanol precipitation |
| Extract Enrichment: | Lyophilization |
| Sample Resuspension: | 500 uL 50mM sodium phosphate buffer in Deuterium Oxide (D2O) |
| Sample Spiking: | CaFormate internal standard |
