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MB Sample ID: SA005926
| Local Sample ID: | IE05-10 |
| Subject ID: | SU000126 |
| Subject Type: | Animal |
| Subject Species: | Mirounga angustirostris |
| Taxonomy ID: | 9716 |
| Species Group: | Mammal |
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Treatment:
| Treatment ID: | TR000128 |
| Treatment Summary: | Seventeen northern elephant seal pups constituting four different cohorts at Año Nuevo State Reserve were studied at two post-weaning periods: early (1-2 wk post weaning; n=5) and late (6-7 weeks post weaning; n=12). Study #1: Prior to each infusion protocol, plasma U/kg). Following the infusion, blood samples were collected at 10,To determine the effects of prolonged fasting on peripheral insulin activity and function, samples were collected. Ten fasting seal pups (n=5 early, n=5 late) were infused (i.v.) with a mass-specific dose of insulin (0.065 U/kg). Following the infusion, blood samples were collected at 10, 30, 60, 90, and 120 minutes. Study #2: Seven, late-fasted seal pups were administered either a low (LDG; 10 pmol/kg; n=3) or high (HDG; 100 pmol/kg; n=4) dose of GLP-1 immediately following a glucose bolus (0.5 g/kg) (i.v.) infused within 2 mins. the infusions, blood samples were collected at 10, 30, 60, 90, 120, and 150 minutes. |
| Treatment Protocol Filename: | Newman_Lab-Endocannabinoid_Extraction_Analysis_Protocol-Ortiz_WCMC.pdf Newman_Lab_NEFA_SOPs-Ortiz_WCMC_Pilot.pdf |
| Treatment Compound: | GLP-1 or Insulin |
| Treatment Route: | Infusion |
| Treatment Dose: | low (10 pmol/kg) or high (100 pmol/kg) dose of GLP-1, insulin (0.065 U/kg) |
| Animal Fasting: | Yes, for insulin study |
