Metabolomics Workbench : NIH Data Repository

MB Sample ID: SA071301

Local Sample ID:	C-1FRW2-U-00
Subject ID:	SU001090
Subject Type:	Human
Subject Species:	Homo sapiens
Taxonomy ID:	9606

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Treatment:

Treatment ID:	TR001104
Treatment Summary:	This study will use a cross-sectional design and nested case control comparison of inner-city children with poorly controlled asthma versus those with well-controlled asthma. Participants will be eligible for the study if they attend one of the inner-city schools sampled in SICAS-2 and have a physician diagnosis of asthma. SICAS2 is a factorial randomized double-blinded, placebo-controlled classroom air cleaner intervention [High Efficiency Particulate Air (HEPA) filter/purifying units]/ integrated pest management (IPM) intervention. Baseline Clinical measures: Prior to randomization (a) at a clinic visit we will assess clinical characteristics (asthma symptoms, health care utilization, home characteristics); pulmonary function, FeNO, and allergen sensitivities, and (b) we will assess and sample the school/classroom environment and product use. Parental/child report of personal care product use and dietary history will be ascertained from each study participant. Clinical Follow-up: Enrolled students with asthma, randomized to treatment group by school (IPM) and classroom (HEPA) will be followed during the academic school year. Follow-up phone health outcomes surveys (e.g., symptoms, health care use; time-activity) will be conducted every 2 months after baseline, yielding evenly-spaced follow-up measures during the school year and 1 after school ends. Home environmental measures will be collected twice by dust sampling. Follow-up school/classroom visits will be conducted twice in opposite seasons to assess/collect week-long environmental classroom allergen/mold/NO2/pollution/endotoxin levels in the dust and air. Classroom/School/Home Exposure Data: The CHEAR resources will support critical analysis of urinary biomarkers at pre-intervention (baseline) during the academic school year prior to randomization and intervention. Urine specimens have been collected from 103 children with asthma at baseline over the first 2 years of the intervention study. These specimens can be linked to classroom/school allergen, mold and air sampling and school environmental questionnaires as well as enrolled students and longitudinal health outcome measures including pulmonary function testing and FeNO measurements.

Treatment ID:

TR001104

Treatment Summary:

This study will use a cross-sectional design and nested case control comparison of inner-city children with poorly controlled asthma versus those with well-controlled asthma. Participants will be eligible for the study if they attend one of the inner-city schools sampled in SICAS-2 and have a physician diagnosis of asthma. SICAS2 is a factorial randomized double-blinded, placebo-controlled classroom air cleaner intervention [High Efficiency Particulate Air (HEPA) filter/purifying units]/ integrated pest management (IPM) intervention. Baseline Clinical measures: Prior to randomization (a) at a clinic visit we will assess clinical characteristics (asthma symptoms, health care utilization, home characteristics); pulmonary function, FeNO, and allergen sensitivities, and (b) we will assess and sample the school/classroom environment and product use. Parental/child report of personal care product use and dietary history will be ascertained from each study participant. Clinical Follow-up: Enrolled students with asthma, randomized to treatment group by school (IPM) and classroom (HEPA) will be followed during the academic school year. Follow-up phone health outcomes surveys (e.g., symptoms, health care use; time-activity) will be conducted every 2 months after baseline, yielding evenly-spaced follow-up measures during the school year and 1 after school ends. Home environmental measures will be collected twice by dust sampling. Follow-up school/classroom visits will be conducted twice in opposite seasons to assess/collect week-long environmental classroom allergen/mold/NO2/pollution/endotoxin levels in the dust and air. Classroom/School/Home Exposure Data: The CHEAR resources will support critical analysis of urinary biomarkers at pre-intervention (baseline) during the academic school year prior to randomization and intervention. Urine specimens have been collected from 103 children with asthma at baseline over the first 2 years of the intervention study. These specimens can be linked to classroom/school allergen, mold and air sampling and school environmental questionnaires as well as enrolled students and longitudinal health outcome measures including pulmonary function testing and FeNO measurements.