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MB Sample ID: SA084695
| Local Sample ID: | DHA_unRBC_0h_C |
| Subject ID: | SU001271 |
| Subject Type: | Cultured cells |
| Subject Species: | Plasmodium falciparum;Homo sapiens |
| Taxonomy ID: | 5833;9606 |
| Genotype Strain: | 3D7 |
| Age Or Age Range: | 28-34 h post invasion |
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Treatment:
| Treatment ID: | TR001286 |
| Treatment Summary: | Trophozoite-stage P. falciparum infected RBCs (10% parasitaemia and 2% Hct) were treated with OZ277 (300 nM), OZ439 (300 nM), DHA (100 nM) or an equivalent volume of DMSO (0.03%) for 0, 3, 6 and 9 h. During the drug incubation period parasites were at 37°C under a gas atmosphere of 94% N2, 5% CO2 and 1% O2. |
| Treatment Compound: | OZ277 (arterolane), OZ439 (artefenomel) and dihydroartemisinin (DHA) |
| Treatment Vehicle: | DMSO |
| Cell Media: | Complete RPMI medium (10.4 g/L) containing HEPES (5.94 g/L), hypoxanthine (50 mg/L), sodium bicarbonate (2.1 g/L) and Albumax II (5 g/L). |
| Cell Media Lastchanged: | Immediately prior to initiation of drug incubation |
