Metabolomics Workbench : NIH Data Repository

MB Sample ID: SA125545

Local Sample ID:	13206370
Subject ID:	SU001564
Subject Type:	Human
Subject Species:	Homo sapiens
Taxonomy ID:	9606
Age Or Age Range:	18-45
Gender:	Male and female
Human Nutrition:	Low glycemic load and high glycemic load diet
Human Inclusion Criteria:	We recruited non-smoking, healthy individuals between the ages of 18-45 years from the Greater Seattle area.
Human Exclusion Criteria:	Exclusion criteria consisted of impaired fasting glucose (fasting blood glucose ≥5.6 mmol/L), any physician-diagnosed condition requiring a restricted diet, food allergies, regular use of hormones or anti-inflammatory medication, current pregnancy or lactation or plans to become pregnant, or heavy use of alcohol (>2 drinks/d)

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Treatment:

Treatment ID:	TR001579
Treatment Summary:	A 7-day rotating menu was created for each diet. At baseline, participants completed a 3-d food record to estimate mean daily calorie intake. Energy intake from the food records along with weight, height, sex and activity level were used to estimate each participant’s daily energy needs necessary to maintain the current weight. The estimated calorie intake was used to adjust the 7-day rotating menu to meet each participant’s needs so that they would remain weight stable during the study. The percentage energy from macronutrients of the two diets were identical: 15% energy from protein, 30% energy from fat, and 55% energy from carbohydrate. The LGL diet provided on average 55 g/d of fiber and 77 g/d of fructose, with a GL of 125 (Table 1). The HGL diet substituted refined grains for whole grains, included other carbohydrates from high-glycemic index food sources and provided on average 28 g/d of fiber and 26 g/d of fructose, with a GL of 250. All food was prepared and provided by the Fred Hutch Human Nutrition Laboratory (HNL) during the intervention. Weekday dinners were consumed under supervision at the HNL, and the next day’s breakfast, lunch and snacks were portioned, packaged and taken home for consumption. Examples of study menus and detail on diet consumption have been published previously (Neuhouser et al. 2012).

Treatment ID:

TR001579

Treatment Summary:

A 7-day rotating menu was created for each diet. At baseline, participants completed a 3-d food record to estimate mean daily calorie intake. Energy intake from the food records along with weight, height, sex and activity level were used to estimate each participant’s daily energy needs necessary to maintain the current weight. The estimated calorie intake was used to adjust the 7-day rotating menu to meet each participant’s needs so that they would remain weight stable during the study. The percentage energy from macronutrients of the two diets were identical: 15% energy from protein, 30% energy from fat, and 55% energy from carbohydrate. The LGL diet provided on average 55 g/d of fiber and 77 g/d of fructose, with a GL of 125 (Table 1). The HGL diet substituted refined grains for whole grains, included other carbohydrates from high-glycemic index food sources and provided on average 28 g/d of fiber and 26 g/d of fructose, with a GL of 250. All food was prepared and provided by the Fred Hutch Human Nutrition Laboratory (HNL) during the intervention. Weekday dinners were consumed under supervision at the HNL, and the next day’s breakfast, lunch and snacks were portioned, packaged and taken home for consumption. Examples of study menus and detail on diet consumption have been published previously (Neuhouser et al. 2012).