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MB Sample ID: SA155506

Local Sample ID:HFD-DEN_3D20.1T
Subject ID:SU001764
Subject Type:Mammal
Subject Species:Mus musculus
Taxonomy ID:10090
Genotype Strain:C57Bl/6N
Age Or Age Range:35 weeks
Gender:Male
Animal Animal Supplier:KU Leuven Animal Laboratory
Animal Feed:control diet (E15742-33 ssniff Spezialdiäten GmbH) or 60% high fat diet (S8655-E220 sniff Spezialdiäten GmbH)

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Treatment:

Treatment ID:TR001777
Treatment Summary:2-week old mice were injected i.p. diethylnitrosamine (DEN, 25 mg/Kg) in phosphate buffered saline (3.17 mg/ml). At 6-weeks of age, mice were randomized into two groups: control diet (CD, E15742-33 ssniff Spezialdiäten GmbH) or high fat diet (HFD, S8655-E220 sniff Spezialdiäten GmbH).
Treatment Compound:dietylnitrosamine (DEN)
Treatment Route:i.v.
Treatment Dose:25mg/kg
Treatment Doseduration:single dose at 2-weeks age
Treatment Vehicle:phosphate buffered saline (PBS)
Animal Endp Euthanasia:50 µl of 60 mg/ml Nembutal solution (Vetoquinol)
Animal Endp Clinical Signs:20% increase in abdomen diameter and hard mass detection via palpation, loss of ambulation, loss of skin elasticity, labored respiration, or weight loss over 20 % of initial body weight
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