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MB Sample ID: SA181895

Local Sample ID:	Diabetes-HPVB-3
Subject ID:	SU002013
Subject Type:	Mammal
Subject Species:	Macaca fascicularis
Taxonomy ID:	9541
Age Or Age Range:	16.3 - 18.8 yo
Weight Or Weight Range:	5.73 - 10.56 kg
Gender:	Male
Animal Animal Supplier:	Guangzhou Huazhen Biosciences Co., Ltd, Guangzhou
Animal Housing:	Guangzhou Huazhen Biosciences Co., Ltd, Guangzhou
Animal Light Cycle:	12-h/12-h light-dark cycle
Animal Feed:	normal food (19.26 % protein, 5% fat, no sugar, and no cholesterol), or high-fat and high-sugar (HFHS) food (≥ 30% sugar, ≥ 15% fat, ≥ 10.5% protein, and ≥ 0.5% cholesterol)
Animal Inclusion Criteria:	spontaneous diabetes mellitus and HFHS food-fed

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Treatment:

Treatment ID:	TR002025
Treatment Summary:	Male Macaca fascicularis of about 18 years old were bought from Huazhen Biosciences (Guangzhou, China). All macaques were born from 16th August 2001 to 11th February 2004 (Supplemental Table S1) and housed in the animal rooms maintained at 16 ~ 26 °C and 40% ~ 70% room humidity on a 12-h/12-h light-dark cycle. All macaques of both NC and sDM groups were fed with the normal food (19.26 % protein, 5% fat, no sugar, and no cholesterol), whereas the HFHS monkeys were grown up on the same diet until switching to the high-fat and high-sugar (HFHS) food (≥ 30% sugar, ≥ 15% fat, ≥ 10.5% protein, and ≥ 0.5% cholesterol) on 1st March 2019 (Fig. 1a). After one year of food change, blood and urine samples were collected.

Treatment ID:

TR002025

Treatment Summary:

Male Macaca fascicularis of about 18 years old were bought from Huazhen Biosciences (Guangzhou, China). All macaques were born from 16th August 2001 to 11th February 2004 (Supplemental Table S1) and housed in the animal rooms maintained at 16 ~ 26 °C and 40% ~ 70% room humidity on a 12-h/12-h light-dark cycle. All macaques of both NC and sDM groups were fed with the normal food (19.26 % protein, 5% fat, no sugar, and no cholesterol), whereas the HFHS monkeys were grown up on the same diet until switching to the high-fat and high-sugar (HFHS) food (≥ 30% sugar, ≥ 15% fat, ≥ 10.5% protein, and ≥ 0.5% cholesterol) on 1st March 2019 (Fig. 1a). After one year of food change, blood and urine samples were collected.