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MB Sample ID: SA181898
Local Sample ID: | Diabetes-Liver-3 |
Subject ID: | SU002013 |
Subject Type: | Mammal |
Subject Species: | Macaca fascicularis |
Taxonomy ID: | 9541 |
Age Or Age Range: | 16.3 - 18.8 yo |
Weight Or Weight Range: | 5.73 - 10.56 kg |
Gender: | Male |
Animal Animal Supplier: | Guangzhou Huazhen Biosciences Co., Ltd, Guangzhou |
Animal Housing: | Guangzhou Huazhen Biosciences Co., Ltd, Guangzhou |
Animal Light Cycle: | 12-h/12-h light-dark cycle |
Animal Feed: | normal food (19.26 % protein, 5% fat, no sugar, and no cholesterol), or high-fat and high-sugar (HFHS) food (≥ 30% sugar, ≥ 15% fat, ≥ 10.5% protein, and ≥ 0.5% cholesterol) |
Animal Inclusion Criteria: | spontaneous diabetes mellitus and HFHS food-fed |
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Treatment:
Treatment ID: | TR002025 |
Treatment Summary: | Male Macaca fascicularis of about 18 years old were bought from Huazhen Biosciences (Guangzhou, China). All macaques were born from 16th August 2001 to 11th February 2004 (Supplemental Table S1) and housed in the animal rooms maintained at 16 ~ 26 °C and 40% ~ 70% room humidity on a 12-h/12-h light-dark cycle. All macaques of both NC and sDM groups were fed with the normal food (19.26 % protein, 5% fat, no sugar, and no cholesterol), whereas the HFHS monkeys were grown up on the same diet until switching to the high-fat and high-sugar (HFHS) food (≥ 30% sugar, ≥ 15% fat, ≥ 10.5% protein, and ≥ 0.5% cholesterol) on 1st March 2019 (Fig. 1a). After one year of food change, blood and urine samples were collected. |