Summary of Study ST002719
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001686. The data can be accessed directly via it's Project DOI: 10.21228/M8S13H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002719 |
| Study Title | Comparison of metabolic of A549 cells before and after Gossypol acetate (GAA) treatment |
| Study Summary | GAA is a natural product with anti-cancer application prospect, but its anti-tumor molecular mechanism is still controversial. Previous studies have showed that GAA can suppress the expression of mitochondrial DNA encoded proteins by targeting LRPPRC, suggesting that GAA may affect mitochondrial metabolism. Here, metabonomics was applied to study of effect of GAA on central carbon metabolism in A549 cells. The metabolomic data showed that GAA significantly decreased tricarboxylic acid cycle ralated metabolites and significantly increased glycolysis-related metabolites. These results indicated that GAA could inhibite oxidative phosphorylation in A549 cells. |
| Institute | Hangzhou Institute of Medicine (HIM), University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Chinese Academy of Sciences |
| Last Name | Zhou |
| First Name | Wei |
| Address | Banshan Road |
| zhouwei1989@iccas.ac.cn | |
| Phone | 057188122431 |
| Submit Date | 2023-05-23 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-06-21 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN004408 |
|---|---|
| Analysis type | MS |
| Chromatography type | HILIC |
| Chromatography system | Nexera UHPLC LC-30A |
| Column | Merck SeQuant ZIC-pHILIC (100 x 2.1mm,5um) |
| MS Type | ESI |
| MS instrument type | Triple quadrupole |
| MS instrument name | ABI Sciex API 6500 QTrap |
| Ion Mode | POSITIVE |
| Units | relative intensity |
