Summary of Study ST001915
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001208. The data can be accessed directly via it's Project DOI: 10.21228/M8JX2X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001915 |
Study Title | Myocardial Rev-erb-mediated diurnal metabolic rhythm( Part1/3) |
Study Summary | Agonists and antagonists of nuclear receptor Rev-erbα/β, key components of the circadian clock, can benefit the heart. Here, we show that mice with cardiomyocyte-specific knockout (KO) of Rev-erbα/β display progressive cardiac dilation and lethal heart failure. Inducible ablation of Rev-erbα/β in adult hearts causes similar phenotypes. Impaired fatty acid oxidation in the KO myocardium, particularly in the light cycle, precedes contractile dysfunctions with a reciprocal overreliance on carbohydrate utilization, particularly in the dark cycle. These findings delineate temporal coordination between clock-mediated anticipation and nutrient-induced response in myocardial metabolism. |
Institute | Baylor College of Medicine |
Last Name | Song |
First Name | Shiyang |
Address | One Baylor Plaza, Houston, Texas, 77030, USA |
shiyangs@bcm.edu | |
Phone | 7137983159 |
Submit Date | 2021-09-10 |
Raw Data Available | Yes |
Analysis Type Detail | LC-MS |
Release Date | 2022-12-24 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN003113 |
---|---|
Analysis type | MS |
Chromatography type | GC |
Chromatography system | Shimadzu Nexera X2 |
Column | Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um) |
MS Type | EI |
MS instrument type | Other |
MS instrument name | Shimadzu QP2010 Plus |
Ion Mode | UNSPECIFIED |
Units | pmoles/l |
Chromatography:
Chromatography ID: | CH002298 |
Instrument Name: | Shimadzu Nexera X2 |
Column Name: | Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um) |
Chromatography Type: | GC |