Summary of Study ST002313

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001483. The data can be accessed directly via it's Project DOI: 10.21228/M81M72 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002313
Study TitleDietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology, increases oxidative stress, alters metabolism and causes gut dybiosis in APCmin mice
Study SummaryColorectal cancer (CRC) is the second most prevelant malignancy in Europe and diet is an important modifiable risk factor. Processed meat consumption, including meats with preservative salts such as sodium nitrite, have been implicated in CRC pathogenesis. This study investigated how the CRC pathology and metabolic status of adenomatous polyposis coli (APC) multiple intestinal neoplasia (min) mice was perturbed following 8 weeks of pork meat consumption.Dietary inclusions (15%) of either nitrite-free pork, nitrite-free sausage or nitrite-containing sausage (frankfurter) were compared against a parallel control group (100% chow). Comprehensive studies investigated: gastrointestinal tract histology (tumours, aberant crypt foci (ACF) and mucin deplin foci (MDF), lipid peroxidation (urine and serum), faecal microbiota and serum metabolomics (599 metabolites).
Institute
Institute for Global Food Security
Last NamePan
First NameXiaobei
Address19 Chlorine Gardens, Belfast, Antrim, BT9 5DL, United Kingdom
Emailx.pan@qub.ac.uk
Phone02890975984
Submit Date2022-09-20
Raw Data AvailableYes
Raw Data File Type(s)raw(Waters)
Analysis Type DetailLC-MS
Release Date2022-11-03
Release Version1
Xiaobei Pan Xiaobei Pan
https://dx.doi.org/10.21228/M81M72
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN003779 AN003780
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Waters Acquity I-Class Waters Acquity I-Class
Column Biocrates Quant500 Biocrates Quant500
MS Type ESI ESI
MS instrument type Triple quadrupole Triple quadrupole
MS instrument name Waters Xevo-TQ-S Waters Xevo-TQ-S
Ion Mode POSITIVE NEGATIVE
Units uM uM

Chromatography:

Chromatography ID:CH002794
Instrument Name:Waters Acquity I-Class
Column Name:Biocrates Quant500
Chromatography Type:Reversed phase
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