Summary of Study ST000020
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000019. The data can be accessed directly via it's Project DOI: 10.21228/M8TG6F This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000020 |
Study Title | Biomarker Discovery in Knee Osteoarthritis (I) |
Study Type | Biomarker Discovery in Knee Osteoarthritis |
Study Summary | The goal of the study was to determine whether there is a set of metabolites that differentiate people who have knee OA and show radiographic disease progression over 18 months from those who have knee OA and do not show disease progression over the same time period. |
Institute | University of North Carolina |
Department | Systems and Translational Sciences |
Laboratory | Sumner Lab |
Last Name | Sumner |
First Name | Susan |
Address | Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081 |
susan_sumner @unc.edu | |
Phone | 704-250-5066 |
Submit Date | 2014-02-28 |
Num Groups | 4 |
Total Subjects | 88 |
Raw Data Available | Yes |
Raw Data File Type(s) | fid |
Uploaded File Size | 53 M |
Analysis Type Detail | NMR |
Release Date | 2018-08-27 |
Release Version | 1 |
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Collection:
Collection ID: | CO000020 |
Collection Summary: | Urine samples (early morning [second morning void) after a 10-hour fast]) collected from 44 overweight or obese participants in the IDEA trial at baseline and at 18 months of follow-up were selected from two subgroups (n=22 each): a group that exhibited radiographic progression and an age, race, sex, and BMI matched group who did not progress. Progression was defined radiographically by a ≥ 0.7mm decrease in medial JSW from baseline to 18 months while non-progression was defined as a decrease in medial JSW of ≤0.35mm . All subjects experienced knee pain and had radiographic evidence of tibiofemoral OA. For those people who were assigned an intervention that included exercise, the 18-month samples were collected at least 24 hours after the last acute bout of exercise training. In addition sampling was postponed (1-2 weeks after recovery from symptoms) in the event of an acute respiratory, urinary tract, or other infection. Urine was aliquoted and stored in cryovials at -80°C. |
Sample Type: | Urine |
Collection Frequency: | Baseline and after 18 month (Follow up) |
Volumeoramount Collected: | 1.8 mL of urine |
Storage Conditions: | 80C. |