Summary of Study ST000433
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000335. The data can be accessed directly via it's Project DOI: 10.21228/M8HS40 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000433 |
| Study Title | Plasma sphingolipid changes with autopsy-confirmed Lewy body or Alzheimer's pathology |
| Study Type | targeted sphingolipid and fatty acid analyses |
| Study Summary | We identified four groups with available plasma 2 years before death: high (n = 12) and intermediate-likelihood DLB (n = 14) based on the third report of the DLB consortium; dementia with Alzheimer's pathology (AD; n = 18); and cognitively normal with normal aging pathology (n = 21). Lipids were measured using ESI/MS/MS. |
| Institute | Mayo Clinic |
| Department | Department of Neurology |
| Laboratory | Mayo Clinic Metabolomics Resource Core |
| Last Name | Mielke |
| First Name | Michelle |
| Address | 200 First Street SW, Rochester, MN 55905 |
| Mielke.Michelle@mayo.edu | |
| Phone | 507-293-1069 |
| Submit Date | 2016-07-22 |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2016-09-23 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO000448 |
| Collection Summary: | All blood samples in the Mayo Clinic ADRC are collected from nonfasting participants in the sitting position in a clinical laboratory. Serum tubes (red-top) are drawn first, followed by EDTA plasma tubes. Blood is drawn from the median cubital vein with a 21 g needle and typically centrifuged at 2000 g for 10 minutes at 4°C. The serum and plasma are aliquoted into 0.5 mL and stored in a −80°C freezer until use. None of the aliquots were thawed before being pulled to measure the sphingolipids and fatty acids. We have previously shown that long-term storage, up to 38 years, in long-term −80°C freezers does not affect sphingolipid levels [26]. |
| Sample Type: | Blood |
