Summary of Study ST001901

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001196. The data can be accessed directly via it's Project DOI: 10.21228/M83X4N This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001901
Study TitleMitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress
Study SummaryAmino acids are essential building blocks of life. However, increasing evidence suggests that elevated amino acids cause cellular toxicity associated with numerous metabolic disorders. How cells cope with elevated amino acids remains poorly understood. Here, we show that a previously identified cellular structure, the mitochondrial-derived compartment (MDC), functions to protect cells from amino acid stress. In response to amino acid elevation, MDCs are generated from mitochondria, where they selectively sequester and deplete SLC25A nutrient carriers and their associated import receptor Tom70 from the organelle. Generation of MDCs promotes amino acid catabolism, and their formation occurs simultaneously with transporter removal at the plasma membrane via the multi-vesicular body (MVB) pathway. Combined loss of vacuolar amino acid storage, MVBs and MDCs renders cells sensitive to high amino acid stress. Thus, we propose that MDCs operate as part of a coordinated cell network that facilitates amino acid homoeostasis through post-translational nutrient transporter remodeling.
University of Utah School of Medicine
LaboratoryHughes Lab
Last NameHughes
First NameAdam
Address15 N Medical Drive East, RM 4100, Salt Lake City, UT, 84112, USA
Submit Date2021-07-22
Raw Data AvailableYes
Raw Data File Type(s)cdf
Analysis Type DetailGC-MS
Release Date2021-08-25
Release Version1
Adam Hughes Adam Hughes application/zip

Select appropriate tab below to view additional metadata details:


Collection ID:CO001972
Collection Summary:See STAR methods file
Collection Protocol Filename:STAR_methods.pdf
Sample Type:Yeast cells