Summary of Study ST002086
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001325. The data can be accessed directly via it's Project DOI: 10.21228/M8FM6D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002086 |
| Study Title | Serum NMR profiling reveals differential alterations in the lipoproteome induced by Pfizer-BioNTech vaccine in COVID-19–recovered subjects and naïve subjects |
| Study Type | NMR-based metabolomics |
| Study Summary | 1H NMR spectra of sera have been used to define the changes induced by vaccination with Pfizer-BioNTech vaccine (2 shots, 21 days apart) in 10 COVID-19-recovered subjects and 10 COVID-19-naïve subjects at different time points, starting from before vaccination, then weekly until 7 days after second injection, and finally 1 month after the second dose. The data show that vaccination does not induce any significant variation in the metabolome, whereas it causes changes at the level of lipoproteins. The effects are different in the COVID-19-recovered subjects with respect to the naïve subjects, suggesting that a previous infection reduces the vaccine modulation of the lipoproteome composition. |
| Institute | University of Florence |
| Last Name | Ghini |
| First Name | Veronica |
| Address | via Luigi Sacconi |
| ghini@cerm.unifi.it | |
| Phone | 03922800462 |
| Submit Date | 2022-02-14 |
| Num Groups | 2 |
| Total Subjects | 20 |
| Num Males | 7 |
| Num Females | 13 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2022-02-28 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO002163 |
| Collection Summary: | For all subjects blood serum samples were collected at six different time points: before the first dose (T0); 7 and 14 days after the first dose (T7 and T14, respectively); 21 days after the first dose, just before the second dose (T21); 28 days after the first dose and 7 days after the second dose (T28); 1 month after the second dose (T1M). Blood samples were collected (4 hours after breakfast) in a BD vacutainer clot-activator tube for serum collection and processed within one hour from sample collection. After processing, all the serum samples were immediately stored at -30°C until NMR analysis. |
| Sample Type: | Blood (serum) |
| Storage Conditions: | Described in summary |
| Collection Vials: | BD vacutainer clot-activator tube for serum |
