Summary of Study ST002091
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001327. The data can be accessed directly via it's Project DOI: 10.21228/M8641H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002091 |
| Study Title | Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico |
| Study Summary | A nested case-control study was conducted with a sample of 98 NAFLD cases and 100 healthy controls who are participating in an on-going, longitudinal study in Mexico. NAFLD cases were clinically confirmed using elevated liver enzyme tests and liver ultrasound or liver ultrasound elastography, after excluding alcohol abuse, and 100 controls were identified as having at least two consecutive normal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (< 40 U/L) results in a 6-month period, and a normal liver ultrasound elastography result in January 2018. Samples were analyzed on the Sciex Lipidyzer Platform and quantified with normalization to serum volume. As many as 1100 lipid species can be identified using the Lipidyzer targeted multiple-reaction monitoring list. The association between serum lipids and NAFLD was investigated using analysis of covariance, random forest analysis, and by generating receiver operator characteristic (ROC) curves. |
| Institute | University of California, Los Angeles |
| Department | Biological Chemistry |
| Laboratory | UCLA Lipidomics |
| Last Name | Williams |
| First Name | Kevin |
| Address | BSRB 257, 615 Charles E. Young Drive S., Los Angeles, CA, 90095 |
| lipidomics@mednet.ucla.edu | |
| Phone | 3108254397 |
| Submit Date | 2022-02-09 |
| Num Groups | 2 |
| Total Subjects | 200 |
| Num Males | 52 |
| Num Females | 148 |
| Publications | PMID: 34629052 PMCID: PMC8504048 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | MS(Dir. Inf.) |
| Release Date | 2022-03-18 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO002168 |
| Collection Summary: | A convenience sample of 98 NAFLD cases and 100 healthy controls aged 36 to 78 years, who are long-term participants in the HWCS was used for the current pilot study. The inclusion criteria for this study were having a hepatologist-confirmed diagnosis of NAFLD for the cases, and a history of normal ALT and AST results (< 40 U/L) plus a normal ultrasound elastography result for the controls. Liver enzymes (ALT, AST), total cholesterol, high-density lipoprotein (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, glucose, body mass index (BMI), waist circumference, and blood pressure were measured. Participants reported fasting for ≥12 h at blood draw. Serum samples that were collected during 2011–2013 and stored at − 70 °C, as well as self-reported data and laboratory results that were obtained during the same time period, were used for the cases and controls. https://pubmed.ncbi.nlm.nih.gov/34629052/ |
| Sample Type: | Blood (serum) |
