Summary of Study ST002770
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001727. The data can be accessed directly via it's Project DOI: 10.21228/M8GD9S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002770 |
| Study Title | Metabolomics and Molecular Networking-Guided Screening of Bacillus-Derived Bioactive Compounds Against a Highly Lethal Vibrio Species |
| Study Summary | During our search for active substances capable of inhibiting a newly discovered highly lethal Vibrio strain vp-HL causing highly lethal Vibrio disease in shrimp (HLVD), we found that the fermentation broth of multiple Bacillus strains exhibited antibacterial activity. However, the substances responsible for the activity remained unclear. Metabolomics was employed in conjunction with bioactivity screening to identify the antibacterial compounds from Bacillus strains. The Ethyl Acetate extracts of the broth of 20 Bacillus strains were analyzed using UPLC-MS/MS. Principal Component Analysis (PCA) and Orthogonal Partial Least Square - Discriminant Analysis (OPLS-DA) was used for pattern recognition. The strains fall into two groups in the scores plot from PCA. The S-plot from OPLS-DA offered information on biomarkers. |
| Institute | Third Institute of Oceanography, Ministry of Natural Resources |
| Last Name | Xia |
| First Name | Jinmei |
| Address | Daxue Rd, Xiamen, China. |
| xiajinmei@tio.org.cn | |
| Phone | 13003995626 |
| Submit Date | 2023-06-29 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-11-01 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO002870 |
| Collection Summary: | The broth cultures were centrifuged at 7000 rpm for 10 min under 4 °C and the supernatants were collected. |
| Sample Type: | Bacterial cells |
