Summary of Study ST000282

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000224. The data can be accessed directly via it's Project DOI: 10.21228/M8K599 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000282
Study TitlePilot Study 13C flux effects when RhoC or RhoA perturbed (13C BCs)
Study Type13C mass isotopomer analysis (flux studies)
Study SummaryRho-GTPases are small GTP-binding proteins that contribute to the epithelial-to-mesenchymal transition by regulating several cellular processes including organization of the actin cytoskeleton, cell motility, transcription, and cell proliferation. Overexpression of RhoC-GTPases (RhoC) in breast cancer has been implicated in poor disease prognosis due to increased cancer cells invasion, migration, and motility, which warranted its consideration as a therapeutic target for inhibiting breast cancer metastasis. Using silencing RNA (siRNA) molecules to knockdown RhoC expression is a promising approach to inhibit breast cancer metastases.
University of Michigan
DepartmentInternal Medicine
LaboratoryMerajver Lab
Last NameWynn
First NameMichelle
AddressUniversity Michigan, 2900 Huron Parkway, Ann Arbor, MI 48105
Submit Date2015-02-11
Num Groups5
Total Subjects16
Raw Data File Type(s)d
Analysis Type DetailGC-MS/LC-MS
Release Date2016-01-13
Release Version1
Michelle Wynn Michelle Wynn application/zip

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Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Cell line 13C Label RhoC overexpression RhoA knockdown RhoC knockdown RhoC drug
SA012306S00017282MCF10A  Glutamine no no no no
SA012307S00017283MCF10A  Glutamine yes no no no
SA012308S00017284MDA-MB-231 Glutamine no no no no
SA012309S00017287MDA-MB-231 Glutamine no no no yes
SA012310S00017286MDA-MB-231 Glutamine no no yes no
SA012311S00017285MDA-MB-231 Glutamine no yes no no
SA012312S00017295SUM149 Glucose no no no no
SA012313S00017293SUM149 Glucose no no no no
SA012314S00017294SUM149 Glucose no no no yes
SA012315S00017290SUM149 Glutamine no no no no
SA012316S00017288SUM149 Glutamine no no no no
SA012317S00017289SUM149 Glutamine no no no yes
SA012318S00017296SUM190 Glucose no no no no
SA012319S00017297SUM190 Glucose no no yes no
SA012320S00017291SUM190 Glutamine no no no no
SA012321S00017292SUM190 Glutamine no no yes no
Showing results 1 to 16 of 16