Summary of Study ST000485

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000367. The data can be accessed directly via it's Project DOI: 10.21228/M8MC7X This work is supported by NIH grant, U2C- DK119886.

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Study IDST000485
Study TitleD2 Glucose Quantifcation of obese patients on a 16 week caloric restriction from plasma
Study Typetimecourse
Study SummaryCaloric restriction (CR) improves insulin sensitivity and reduces the incidence of diabetes in obese individuals. The underlying mechanisms whereby CR improves insulin sensitivity are not clear. We evaluated the effect of 16 weeks of CR on whole-body insulin sensitivity by pancreatic clamp before and after CR in 11 obese participants (BMI = 35 kg/m2) compared with 9 matched control subjects (BMI = 34 kg/m2). Compared with the control subjects, CR increased the glucose infusion rate needed to maintain euglycemia during hyperinsulinemia, indicating enhancement of peripheral insulin sensitivity. This improvement in insulin sensitivity was not accompanied by changes in skeletal muscle mitochondrial oxidative capacity or oxidant emissions, nor were there changes in skeletal muscle ceramide, diacylglycerol, or amino acid metabolite levels. However, CR lowered insulin-stimulated thioredoxin-interacting protein (TXNIP) levels and enhanced nonoxidative glucose disposal. These results support a role for TXNIP in mediating the improvement in peripheral insulin sensitivity after CR.
Institute
Mayo Clinic
DepartmentEndocrinology
LaboratoryMayo Metabolomics Core
Last NameNair
First NameSreekumaran
Address200 First Street SW, Rochester, MN 55905
EmailNair.K@mayo.edu
Phone507-285-2415
Submit Date2016-09-23
PublicationsMechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults. DOI: 10.2337/db15-0675
Raw Data File Type(s)d
Analysis Type DetailGC-MS
Release Date2017-11-20
Release Version1
Sreekumaran Nair Sreekumaran Nair
https://dx.doi.org/10.21228/M8MC7X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id visit time (mins) Category
SA024662MS5023_4_-101 -10 Caloric Restriction
SA024663MS5035_4_-101 -10 Caloric Restriction
SA024664MS5027_4_-101 -10 Caloric Restriction
SA024665MS5017_4_-101 -10 Caloric Restriction
SA024666MS5009_4_-101 -10 Caloric Restriction
SA024667MS5007_4_-101 -10 Caloric Restriction
SA024668MS5011_4_-101 -10 Caloric Restriction
SA024669MS5005_4_-101 -10 Caloric Restriction
SA024670MS5037_4_-101 -10 Caloric Restriction
SA024671MS5013_4_-101 -10 Caloric Restriction
SA024672MS5015_4_-101 -10 Caloric Restriction
SA024673MS5019_4_-101 -10 Control
SA024674MS5031_4_-101 -10 Control
SA024675MS5021_4_-101 -10 Control
SA024676MS5043_4_-101 -10 Control
SA024677MS5029_4_-101 -10 Control
SA024678MS5033_4_-101 -10 Control
SA024679MS5041_4_-101 -10 Control
SA024680MS5025_4_-101 -10 Control
SA024681MS5039_4_-101 -10 Control
SA024742MS5023_6_1201 120 Caloric Restriction
SA024743MS5035_6_1201 120 Caloric Restriction
SA024744MS5005_6_1201 120 Caloric Restriction
SA024745MS5017_6_1201 120 Caloric Restriction
SA024746MS5011_6_1201 120 Caloric Restriction
SA024747MS5027_6_1201 120 Caloric Restriction
SA024748MS5013_6_1201 120 Caloric Restriction
SA024749MS5015_6_1201 120 Caloric Restriction
SA024750MS5009_6_1201 120 Caloric Restriction
SA024751MS5037_6_1201 120 Caloric Restriction
SA024752MS5007_6_1201 120 Caloric Restriction
SA024753MS5031_6_1201 120 Control
SA024754MS5039_6_1201 120 Control
SA024755MS5041_6_1201 120 Control
SA024756MS5033_6_1201 120 Control
SA024757MS5019_6_1201 120 Control
SA024758MS5025_6_1201 120 Control
SA024759MS5021_6_1201 120 Control
SA024760MS5043_6_1201 120 Control
SA024761MS5029_6_1201 120 Control
SA024762MS5037_7_1401 140 Caloric Restriction
SA024763MS5027_7_1401 140 Caloric Restriction
SA024764MS5035_7_1401 140 Caloric Restriction
SA024765MS5005_7_1401 140 Caloric Restriction
SA024766MS5013_7_1401 140 Caloric Restriction
SA024767MS5017_7_1401 140 Caloric Restriction
SA024768MS5011_7_1401 140 Caloric Restriction
SA024769MS5007_7_1401 140 Caloric Restriction
SA024770MS5009_7_1401 140 Caloric Restriction
SA024771MS5015_7_1401 140 Caloric Restriction
SA024772MS5023_7_1401 140 Caloric Restriction
SA024773MS5029_7_1401 140 Control
SA024774MS5043_7_1401 140 Control
SA024775MS5019_7_1401 140 Control
SA024776MS5031_7_1401 140 Control
SA024777MS5021_7_1401 140 Control
SA024778MS5039_7_1401 140 Control
SA024779MS5025_7_1401 140 Control
SA024780MS5033_7_1401 140 Control
SA024781MS5041_7_1401 140 Control
SA024782MS5023_8_1601 160 Caloric Restriction
SA024783MS5007_8_1601 160 Caloric Restriction
SA024784MS5015_8_1601 160 Caloric Restriction
SA024785MS5009_8_1601 160 Caloric Restriction
SA024786MS5027_8_1601 160 Caloric Restriction
SA024787MS5017_8_1601 160 Caloric Restriction
SA024788MS5013_8_1601 160 Caloric Restriction
SA024789MS5037_8_1601 160 Caloric Restriction
SA024790MS5011_8_1601 160 Caloric Restriction
SA024791MS5005_8_1601 160 Caloric Restriction
SA024792MS5035_8_1601 160 Caloric Restriction
SA024793MS5041_8_1601 160 Control
SA024794MS5025_8_1601 160 Control
SA024795MS5033_8_1601 160 Control
SA024796MS5039_8_1601 160 Control
SA024797MS5019_8_1601 160 Control
SA024798MS5029_8_1601 160 Control
SA024799MS5031_8_1601 160 Control
SA024800MS5043_8_1601 160 Control
SA024801MS5021_8_1601 160 Control
SA024802MS5023_9_1801 180 Caloric Restriction
SA024803MS5027_9_1801 180 Caloric Restriction
SA024804MS5007_9_1801 180 Caloric Restriction
SA024805MS5017_9_1801 180 Caloric Restriction
SA024806MS5035_9_1801 180 Caloric Restriction
SA024807MS5037_9_1801 180 Caloric Restriction
SA024808MS5013_9_1801 180 Caloric Restriction
SA024809MS5005_9_1801 180 Caloric Restriction
SA024810MS5015_9_1801 180 Caloric Restriction
SA024811MS5011_9_1801 180 Caloric Restriction
SA024812MS5009_9_1801 180 Caloric Restriction
SA024813MS5039_9_1801 180 Control
SA024814MS5029_9_1801 180 Control
SA024815MS5031_9_1801 180 Control
SA024816MS5019_9_1801 180 Control
SA024817MS5043_9_1801 180 Control
SA024818MS5021_9_1801 180 Control
SA024819MS5025_9_1801 180 Control
SA024820MS5033_9_1801 180 Control
SA024821MS5041_9_1801 180 Control
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