Summary of Study ST000513

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000383. The data can be accessed directly via it's Project DOI: 10.21228/M8JG7B This work is supported by NIH grant, U2C- DK119886.

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Study IDST000513
Study TitleInhibition of autophagy/proteasome degradation or inhibition of protein synthesis in models of muscle insulin resistance affect TCA cycle
Study SummaryTo determine which protein degradation pathways downstream of IR and IGF1R contribute to changes in amino acid and mitochondrial metabolite pools, we will treat control, M-IR-/-, MIGIRKO, and HFD obese mice with inhibitors of autophagy or proteasome. We will treat 5 animals each of control, M-IR-/-, MIGIRKO, and HFD mice with vehicle, colchicine to inhibit autophagy, or MG132 to inhibit proteasome activity, then measure TCA cycle in muscle tissue.
Institute
Mayo Clinic
Last NameO'Neill
First NameBrian
AddressOne Joslin Place, Boston, MA 02215
Emailbrian.o'neill@joslin.harvard.edu
Phone617-309-2400
Submit Date2016-12-02
Analysis Type DetailGC-MS
Release Date2018-12-11
Release Version1
Brian O'Neill Brian O'Neill
https://dx.doi.org/10.21228/M8JG7B
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id group genotype
SA026678Sample # 30Control/Colch Irlox
SA026679Sample # 29Control/Colch Irlox
SA026680Sample # 26Control/Colch Irlox IGFRlox
SA026681Sample # 27Control/Colch Irlox IGFRlox
SA026682Sample # 28Control/Colch Irlox IGFRlox
SA026683Sample # 25Control/Colch Irlox IGFRlox
SA026684Sample # 24Control/Colch Irlox IGFRlox
SA026685Sample # 6Control/Saline Irlox
SA026686Sample # 7Control/Saline Irlox
SA026687Sample # 5Control/Saline Irlox
SA026688Sample # 3Control/Saline Irlox IGFRlox
SA026689Sample # 2Control/Saline Irlox IGFRlox
SA026690Sample # 1Control/Saline Irlox IGFRlox
SA026691Sample # 4Control/Saline Irlox IGFRlox
SA026692Sample # 43HFD+Colch Irlox
SA026693Sample # 42HFD+Colch Irlox
SA026694Sample # 45HFD+Colch Irlox
SA026695Sample # 46HFD+Colch Irlox
SA026696Sample # 44HFD+Colch Irlox IGFRlox
SA026697Sample # 20HFD/Saline Irlox
SA026698Sample # 21HFD/Saline Irlox
SA026699Sample # 23HFD/Saline Irlox
SA026700Sample # 19HFD/Saline Irlox
SA026701Sample # 22HFD/Saline Irlox IGFRlox
SA026702Sample # 40IRKO/Colch IR -/-
SA026703Sample # 39IRKO/Colch IR -/-
SA026704Sample # 37IRKO/Colch IR -/-
SA026705Sample # 38IRKO/Colch IR -/-
SA026706Sample # 41IRKO/Colch IR -/-
SA026707Sample # 18IRKO/Saline IR -/-
SA026708Sample # 15IRKO/Saline IR -/-
SA026709Sample # 17IRKO/Saline IR -/-
SA026710Sample # 14IRKO/Saline IR -/-
SA026711Sample # 16IRKO/Saline IR -/-
SA026712Sample # 31MIGIRKO/Colch IR -/- IGFR -/-
SA026713Sample # 36MIGIRKO/Colch IR -/- IGFR -/-
SA026714Sample # 32MIGIRKO/Colch IR -/- IGFR -/-
SA026715Sample # 33MIGIRKO/Colch IR -/- IGFR -/-
SA026716Sample # 34MIGIRKO/Colch IR -/- IGFR -/-
SA026717Sample # 35MIGIRKO/Colch IR -/- IGFR -/-
SA026718Sample # 8MIGIRKO/Saline IR -/- IGFR -/-
SA026719Sample # 13MIGIRKO/Saline IR -/- IGFR -/-
SA026720Sample # 11MIGIRKO/Saline IR -/- IGFR -/-
SA026721Sample # 12MIGIRKO/Saline IR -/- IGFR -/-
SA026722Sample # 9MIGIRKO/Saline IR -/- IGFR -/-
SA026723Sample # 10MIGIRKO/Saline IR -/- IGFR -/-
Showing results 1 to 46 of 46
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