Summary of Study ST000514

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000383. The data can be accessed directly via it's Project DOI: 10.21228/M8JG7B This work is supported by NIH grant, U2C- DK119886.

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Study IDST000514
Study TitleInhibition of autophagy/proteasome degradation or inhibition of protein synthesis in models of muscle insulin resistance affect amino acids metabolites in serum
Study SummaryTo determine which protein degradation pathways downstream of IR and IGF1R contribute to changes in amino acid and mitochondrial metabolite pools, we will treat control, M-IR-/-, MIGIRKO, and HFD obese mice with inhibitors of autophagy or proteasome. We will treat 5 animals each of control, M-IR-/-, MIGIRKO, and HFD mice with vehicle, colchicine to inhibit autophagy, or MG132 to inhibit proteasome activity, then measure amino acid metabolites in serum.
Institute
Mayo Clinic
Last NameO'Neill
First NameBrian
AddressOne Joslin Place, Boston, MA 02215
Emailbrian.o'neill@joslin.harvard.edu
Phone617-309-2400
Submit Date2016-12-02
Analysis Type DetailLC-MS
Release Date2018-12-11
Release Version1
Brian O'Neill Brian O'Neill
https://dx.doi.org/10.21228/M8JG7B
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Group Genotype Treatment
SA026725ms5629-21Control colch Irlox IGFRlox Colch
SA026726ms5629-22Control colch Irlox IGFRlox Colch
SA026727ms5629-20Control colch Irlox IGFRlox Colch
SA026728ms5629-19Control colch Irlox IGFRlox Colch
SA026729ms5629-25Control colch Irlox Colch
SA026730ms5629-24Control colch Irlox Colch
SA026724ms5629-23Control colch - Colch
SA026753ms5629-7control IR -/- IGFR -/- saline
SA026754ms5629-2control Irlox IGFRlox saline
SA026755ms5629-1control Irlox IGFRlox saline
SA026756ms5629-3control Irlox IGFRlox saline
SA026757ms5629-4control Irlox saline
SA026758ms5629-6control Irlox saline
SA026759ms5629-5control Irlox saline
SA026731ms5629-34HFD + Colch Irlox IGFRlox Colch
SA026732ms5629-36HFD + Colch Irlox Colch
SA026733ms5629-33HFD + Colch Irlox Colch
SA026734ms5629-32HFD + Colch Irlox Colch
SA026735ms5629-35HFD + Colch Irlox Colch
SA026736ms5629-17HFD Irlox IGFRlox saline
SA026737ms5629-18HFD Irlox saline
SA026738ms5629-14HFD Irlox saline
SA026739ms5629-16HFD Irlox saline
SA026740ms5629-15HFD Irlox saline
SA026741ms5629-31MIGIRKO colch IR -/- IGFR -/- Colch
SA026742ms5629-27MIGIRKO colch IR -/- IGFR -/- Colch
SA026743ms5629-29MIGIRKO colch IR -/- IGFR -/- Colch
SA026744ms5629-30MIGIRKO colch IR -/- IGFR -/- Colch
SA026745ms5629-26MIGIRKO colch IR -/- IGFR -/- Colch
SA026746ms5629-28MIGIRKO colch IR -/- IGFR -/- Colch
SA026747ms5629-11MIGIRKO IR -/- IGFR -/- saline
SA026748ms5629-13MIGIRKO IR -/- IGFR -/- saline
SA026749ms5629-10MIGIRKO IR -/- IGFR -/- saline
SA026750ms5629-12MIGIRKO IR -/- IGFR -/- saline
SA026751ms5629-9MIGIRKO IR -/- IGFR -/- saline
SA026752ms5629-8MIGIRKO IR -/- IGFR -/- saline
Showing results 1 to 36 of 36
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