Summary of Study ST000637
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000457. The data can be accessed directly via it's Project DOI: 10.21228/M8060Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000637 |
| Study Title | TCA Cycle Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine and Kidney Tissue (part X) |
| Study Summary | We propose to analyze kidney tissue extract and urine samples from SS and SS.Fh1+ transgenic rats in addition to the analysis of urine samples from the DASH2 trial. The analysis of the rat samples will be highly valuable for several reasons. First, it will to take the findings in human subjects back to animal models and prepare us for further mechanistic studies. We hypothesize at least some of the effects of dietary salt intake on metabolite profiles in human will be recapitulated or altered in the SS rat. If this is confirmed, we will have a highly informative animal model ready for mechanistic studies in which we can investigate the functional contribution of specific metabolites to hypertension and the mechanisms involved. Second, the rat study will allow us to take advantage of a new and unique transgenic SS.Fh1+ model that we recently developed that overexpresses fumarase (Fh1) on the genetic background of the SS rat. Fumarase is a TCA cycle enzyme previously implicated in salt-induced hypertension in SS rats. |
| Institute | Mayo Clinic |
| Last Name | Liang |
| First Name | Mingyu |
| Address | Medical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226 |
| mliang@mcw.edu | |
| Phone | 414-955-8539 |
| Submit Date | 2017-06-23 |
| Analysis Type Detail | GC-MS |
| Release Date | 2019-07-17 |
| Release Version | 1 |
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Factors:
Subject type: Rat; Subject species: Rattus norvegicus (Factor headings shown in green)
| mb_sample_id | local_sample_id | sample source | group |
|---|---|---|---|
| SA035951 | ms6103-17 | YCR1 kidney cortex | Transgenic Het |
| SA035952 | ms6103-23 | YCR1 kidney cortex | Transgenic Het |
| SA035953 | ms6103-21 | YCR1 kidney cortex | Transgenic Het |
| SA035954 | ms6103-24 | YCR1 kidney cortex | Transgenic Het |
| SA035955 | ms6103-18 | YCR1 kidney cortex | Transgenic Negative |
| SA035956 | ms6103-22 | YCR1 kidney cortex | Transgenic Negative |
| SA035957 | ms6103-19 | YCR1 kidney cortex | Transgenic Negative |
| SA035958 | ms6103-20 | YCR1 kidney cortex | Transgenic Negative |
| SA035959 | ms6103-16 | YCR1 outer medulla kidney | Transgenic Het |
| SA035960 | ms6103-15 | YCR1 outer medulla kidney | Transgenic Het |
| SA035961 | ms6103-13 | YCR1 outer medulla kidney | Transgenic Het |
| SA035962 | ms6103-9 | YCR1 outer medulla kidney | Transgenic Het |
| SA035963 | ms6103-10 | YCR1 outer medulla kidney | Transgenic Negative |
| SA035964 | ms6103-11 | YCR1 outer medulla kidney | Transgenic Negative |
| SA035965 | ms6103-12 | YCR1 outer medulla kidney | Transgenic Negative |
| SA035966 | ms6103-14 | YCR1 outer medulla kidney | Transgenic Negative |
| SA035967 | ms6103-1 | YCR1 urine | Transgenic Het |
| SA035968 | ms6103-2 | YCR2 urine | Transgenic Negative |
| SA035969 | ms6103-3 | YCR3 urine | Transgenic Negative |
| SA035970 | ms6103-4 | YCR4 urine | Transgenic Negative |
| SA035971 | ms6103-5 | YCR5 urine | Transgenic Het |
| SA035972 | ms6103-6 | YCR6 urine | Transgenic Negative |
| SA035973 | ms6103-7 | YCR7 urine | Transgenic Het |
| SA035974 | ms6103-8 | YCR8 urine | Transgenic Het |
| Showing results 1 to 24 of 24 |
