Summary of Study ST000647

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000460. The data can be accessed directly via it's Project DOI: 10.21228/M8M027 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000647
Study TitleEffects of Exercise on Dystrophic Mouse Muscle Non-Esterified Fatty Acids (part III)
Study SummaryWe will use male C57BL10, mdx, and nNOS-/- mice (n = 10 each group) to characterize the skeletal and cardiac muscle metabolomes. Half of the mice in each group will remain sedentary while the other half will be subjected to a single bout of treadmill exercise to exhaustion. Mice will be euthanized immediately postexercise and blood, hearts, and hindlimb muscles will be harvested and frozen as detailed in the General Methods. The heart and gastrocnemius, soleus, and quadriceps muscles of one hindlimb will be sent to the Mayo Clinic Metabolomics Resource Core. The heart and quadriceps muscle will be used for untargeted metabolomics profiling (LC/MS) while the gastrocnemius and soleus muscles will be used for targeted analyses of amino acids plus amino metabolites, non-esterified fatty acids, and citric acid cycle intermediates.
Institute
Mayo Clinic
Last NameThomas
First NameGail
AddressPenn State Hershey Heart and Vascular Institute Penn State College of Medicine 500 University Drive, MC H047 Hershey, PA 17033
Emailgthomas4@hmc.psu.edu
Phone717-531-0003, ext. 287087
Submit Date2017-06-23
Analysis Type DetailLC-MS
Release Date2019-07-17
Release Version1
Gail Thomas Gail Thomas
https://dx.doi.org/10.21228/M8M027
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Time point Grouping
SA036499ms5944-7Post Run RUN-BL10 Control
SA036500ms5944-9Post Run RUN-BL10 Control
SA036501ms5944-10Post Run RUN-BL10 Control
SA036502ms5944-6Post Run RUN-BL10 Control
SA036503ms5944-8Post Run RUN-BL10 Control
SA036504ms5944-28Post Run RUN-MDX
SA036505ms5944-26Post Run RUN-MDX
SA036506ms5944-30Post Run RUN-MDX
SA036507ms5944-27Post Run RUN-MDX
SA036508ms5944-29Post Run RUN-MDX
SA036509ms5944-18Post Run RUN-nNOS-/-
SA036510ms5944-19Post Run RUN-nNOS-/-
SA036511ms5944-20Post Run RUN-nNOS-/-
SA036512ms5944-17Post Run RUN-nNOS-/-
SA036513ms5944-16Post Run RUN-nNOS-/-
SA036514ms5944-5Sedentary SED-BL10 Control
SA036515ms5944-4Sedentary SED-BL10 Control
SA036516ms5944-3Sedentary SED-BL10 Control
SA036517ms5944-1Sedentary SED-BL10 Control
SA036518ms5944-2Sedentary SED-BL10 Control
SA036519ms5944-25Sedentary SED-MDX
SA036520ms5944-24Sedentary SED-MDX
SA036521ms5944-21Sedentary SED-MDX
SA036522ms5944-22Sedentary SED-MDX
SA036523ms5944-23Sedentary SED-MDX
SA036524ms5944-15Sedentary SED-nNOS-/-
SA036525ms5944-14Sedentary SED-nNOS-/-
SA036526ms5944-11Sedentary SED-nNOS-/-
SA036527ms5944-12Sedentary SED-nNOS-/-
SA036528ms5944-13Sedentary SED-nNOS-/-
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