Summary of study ST000648

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000460. The data can be accessed directly via it's Project DOI: 10.21228/M8M027 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000648
Study TitleEffects of NO Donor Therapy on the Dystrophic Mouse Muscle Amino Acids (part IV)
Study SummaryFor this aim, we will only use male mdx mice. We will study three groups treated for 7 days with vehicle, naproxcinod (i.e., NO-naproxen), or naproxen (n = 10 each group). Two hours after the final treatment, half the mice in each group will be run to exhaustion on a treadmill. The heart and gastrocnemius, soleus, and quadriceps muscles of one hindlimb will be sent to the Mayo Clinic Metabolomics Resource Core. The heart and quadriceps muscle will be used for untargeted metabolomics profiling (LC/MS) while the gastrocnemius and soleus muscles will be used for targeted analyses of amino acids plus amino metabolites, non-esterified fatty acids, and citric acid cycle intermediates.
Mayo Clinic
Last NameThomas
First NameGail
AddressPenn State Hershey Heart and Vascular Institute Penn State College of Medicine 500 University Drive, MC H047 Hershey, PA 17033
Phone717-531-0003, ext. 287087
Submit Date2017-06-23
Analysis Type DetailLC-MS
Release Date2019-07-17
Release Version1
Gail Thomas Gail Thomas application/zip

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Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Time point Grouping
SA036529ms5862-6Post Run RUN-Naproxcinod
SA036530ms5862-8Post Run RUN-Naproxcinod
SA036531ms5862-10Post Run RUN-Naproxcinod
SA036532ms5862-7Post Run RUN-Naproxcinod
SA036533ms5862-9Post Run RUN-Naproxcinod
SA036534ms5862-18Post Run RUN-Naproxen
SA036535ms5862-20Post Run RUN-Naproxen
SA036536ms5862-19Post Run RUN-Naproxen
SA036537ms5862-17Post Run RUN-Naproxen
SA036538ms5862-16Post Run RUN-Naproxen
SA036539ms5862-30Post Run RUN-Vehicle
SA036540ms5862-27Post Run RUN-Vehicle
SA036541ms5862-29Post Run RUN-Vehicle
SA036542ms5862-28Post Run RUN-Vehicle
SA036543ms5862-26Post Run RUN-Vehicle
SA036544ms5862-3Sedentary SED-Naproxcinod
SA036545ms5862-2Sedentary SED-Naproxcinod
SA036546ms5862-4Sedentary SED-Naproxcinod
SA036547ms5862-5Sedentary SED-Naproxcinod
SA036548ms5862-1Sedentary SED-Naproxcinod
SA036549ms5862-13Sedentary SED-Naproxen
SA036550ms5862-14Sedentary SED-Naproxen
SA036551ms5862-15Sedentary SED-Naproxen
SA036552ms5862-12Sedentary SED-Naproxen
SA036553ms5862-11Sedentary SED-Naproxen
SA036554ms5862-21Sedentary SED-Vehicle
SA036555ms5862-22Sedentary SED-Vehicle
SA036556ms5862-23Sedentary SED-Vehicle
SA036557ms5862-24Sedentary SED-Vehicle
SA036558ms5862-25Sedentary SED-Vehicle
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