Summary of Study ST000650
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000460. The data can be accessed directly via it's Project DOI: 10.21228/M8M027 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000650 |
| Study Title | Effects of NO Donor Therapy on the Dystrophic Mouse Muscle TCA Cycle (part VI) |
| Study Summary | For this aim, we will only use male mdx mice. We will study three groups treated for 7 days with vehicle, naproxcinod (i.e., NO-naproxen), or naproxen (n = 10 each group). Two hours after the final treatment, half the mice in each group will be run to exhaustion on a treadmill. The heart and gastrocnemius, soleus, and quadriceps muscles of one hindlimb will be sent to the Mayo Clinic Metabolomics Resource Core. The heart and quadriceps muscle will be used for untargeted metabolomics profiling (LC/MS) while the gastrocnemius and soleus muscles will be used for targeted analyses of amino acids plus amino metabolites, non-esterified fatty acids, and citric acid cycle intermediates. |
| Institute | Mayo Clinic |
| Last Name | Thomas |
| First Name | Gail |
| Address | Penn State Hershey Heart and Vascular Institute Penn State College of Medicine 500 University Drive, MC H047 Hershey, PA 17033 |
| gthomas4@hmc.psu.edu | |
| Phone | 717-531-0003, ext. 287087 |
| Submit Date | 2017-06-23 |
| Analysis Type Detail | GC-MS |
| Release Date | 2019-07-17 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Time point | Grouping |
|---|---|---|---|
| SA036589 | Sample # 6 | Post Run | RUN-Naproxcinod |
| SA036590 | Sample # 8 | Post Run | RUN-Naproxcinod |
| SA036591 | Sample # 10 | Post Run | RUN-Naproxcinod |
| SA036592 | Sample # 7 | Post Run | RUN-Naproxcinod |
| SA036593 | Sample # 9 | Post Run | RUN-Naproxcinod |
| SA036594 | Sample # 18 | Post Run | RUN-Naproxen |
| SA036595 | Sample # 20 | Post Run | RUN-Naproxen |
| SA036596 | Sample # 19 | Post Run | RUN-Naproxen |
| SA036597 | Sample # 17 | Post Run | RUN-Naproxen |
| SA036598 | Sample # 16 | Post Run | RUN-Naproxen |
| SA036599 | Sample # 30 | Post Run | RUN-Vehicle |
| SA036600 | Sample # 27 | Post Run | RUN-Vehicle |
| SA036601 | Sample # 29 | Post Run | RUN-Vehicle |
| SA036602 | Sample # 28 | Post Run | RUN-Vehicle |
| SA036603 | Sample # 26 | Post Run | RUN-Vehicle |
| SA036604 | Sample # 3 | Sedentary | SED-Naproxcinod |
| SA036605 | Sample # 2 | Sedentary | SED-Naproxcinod |
| SA036606 | Sample # 4 | Sedentary | SED-Naproxcinod |
| SA036607 | Sample # 5 | Sedentary | SED-Naproxcinod |
| SA036608 | Sample # 1 | Sedentary | SED-Naproxcinod |
| SA036609 | Sample # 13 | Sedentary | SED-Naproxen |
| SA036610 | Sample # 14 | Sedentary | SED-Naproxen |
| SA036611 | Sample # 15 | Sedentary | SED-Naproxen |
| SA036612 | Sample # 12 | Sedentary | SED-Naproxen |
| SA036613 | Sample # 11 | Sedentary | SED-Naproxen |
| SA036614 | Sample # 21 | Sedentary | SED-Vehicle |
| SA036615 | Sample # 22 | Sedentary | SED-Vehicle |
| SA036616 | Sample # 23 | Sedentary | SED-Vehicle |
| SA036617 | Sample # 24 | Sedentary | SED-Vehicle |
| SA036618 | Sample # 25 | Sedentary | SED-Vehicle |
| Showing results 1 to 30 of 30 |
