Summary of Study ST000843

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000600. The data can be accessed directly via it's Project DOI: 10.21228/M83X2W This work is supported by NIH grant, U2C- DK119886.

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Study IDST000843
Study TitleStatin Immuno-Metabolomics in Asthma (part I)
Study TypePlacebo-controled trial
Study SummaryInnovative and novel therapies are urgently needed for the treatment of patients with severe asthma, especially those who are refractory to standard-of-care bronchodilators and inhaled corticosteroids. The Zeki lab is investigating the role of the mevalonate (MA) pathway, in the pathogenesis of airway inflammation and remodeling. Although statins all inhibit HMGCR in the same manner in terms of enzyme binding site, the statins’ varied physiochemical properties with respect to their polarity (i.e. lipophilicity) result in very different immune and lipid effects. The major significance of this work is to advance a new class of inhaler therapies for asthma; the statins which work by an entirely different mechanism than current ICS/LABA mainstays. Evidence suggests that statins may have an additive benefit to corticosteroids in asthma, thereby confirming a unique mechanism, namely via MVA pathway inhibition. This becomes particularly important in the severe asthma population which is highly corticosteroid-resistant, is poorly controlled with high exacerbation rates and hospitalizations, and has the highest healthcare costs of all asthma phenotypes. In essence, the potential public health impact of even an incremental improvement in asthma symptom control cannot be underestimated. Even the prevention of 1 asthma attack preserves lung function and reduces the adverse personal and financial impact. This study aimed to determine if statin polarity affects airway drug concentration and systemic drug absorption and to determine the effect of inhaled statins on naïve airway immune cell populations and alveolar-capillary membrane and epithelial barrier integrity in healthy rhesus monkeys. In this particular component of the study, we investigated the metabolic effects resulting from the use of statins in these healthy rhesus monkeys. Specifically, the Newman lab analyzed for lipid mediator (oxylipin, endocannabinoid, fatty acid, and nitro lipid) in lung and trachea tissue, plasma, and BAL and bile acid changes in the lung and trachea tissue and plasma.
Institute
University of California, Davis
DepartmentUSDA Western Human Nutrition Research Center
LaboratoryNewman's Lab
Last NameNewman
First NameJohn
Address430 West Health Sciences Dr. Davis, Ca, 95616
EmailJohn.Newman@ars.usda.gov
Phone(530) 752-1009
Submit Date2017-08-09
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2017-10-11
Release Version1
John Newman John Newman
https://dx.doi.org/10.21228/M83X2W
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Animal; Subject species: Macaca mulatta (Factor headings shown in green)

mb_sample_id local_sample_id Treatment Lung Time point (day)
SA046783BAL-AZ-01Control Left Lung -
SA046784AZ 16Control Left Lung -
SA046785AZ 33Control Left Lung -
SA046786BAL-AZ-33Control Left Lung -
SA046787BAL-AZ-34Control Left Lung 12
SA046788AZ 13Control Left Lung 12
SA046789AZ 10Control Left Lung 12
SA046790AZ 45Control Left Lung 12
SA046791BAL-AZ-19Control Left Lung 12
SA046792BAL-AZ-02Control Left Lung 12
SA046793BAL-AZ-04Control Left Lung 8
SA046794AZ 07Control Left Lung 8
SA046795BAL-AZ-09Control Left Lung 8
SA046796BAL-AZ-10Control Left Lung 8
SA046797AZ 30Control Left Lung 8
SA046798AZ 36Control Left Lung 8
SA046799AZ 03Control Right Lung -
SA046800AZ 06Control Right Lung -
SA046801BAL-AZ-07Control Right Lung -
SA046802AZ 32Control Right Lung -
SA046803BAL-AZ-18Control Right Lung -
SA046804AZ 38Control Right Lung 12
SA046805BAL-AZ-26Control Right Lung 12
SA046806AZ 22Control Right Lung 12
SA046807AZ 29Control Right Lung 12
SA046808BAL-AZ-12Control Right Lung 12
SA046809BAL-AZ-22Control Right Lung 12
SA046810AZ 01Control Right Lung 8
SA046811BAL-AZ-14Control Right Lung 8
SA046812BAL-AZ-17Control Right Lung 8
SA046813AZ 24Control Right Lung 8
SA046814BAL-AZ-13Control Right Lung 8
SA046815AZ 39Control Right Lung 8
SA046816AZ 21Pravastatin Left Lung -
SA046817AZ 26Pravastatin Left Lung -
SA046818AZ 23Pravastatin Left Lung 12
SA046819AZ 15Pravastatin Left Lung 12
SA046820AZ 43Pravastatin Left Lung 12
SA046821AZ 44Pravastatin Left Lung 8
SA046822AZ 02Pravastatin Left Lung 8
SA046823AZ 37Pravastatin Left Lung 8
SA046824AZ 40Pravastatin Right Lung -
SA046825AZ 17Pravastatin Right Lung -
SA046826AZ 08Pravastatin Right Lung -
SA046827AZ 31Pravastatin Right Lung 12
SA046828AZ 09Pravastatin Right Lung 12
SA046829AZ 25Pravastatin Right Lung 12
SA046830AZ 14Pravastatin Right Lung 8
SA046831AZ 18Pravastatin Right Lung 8
SA046832BAL-AZ-24Simvastatin Left Lung -
SA046833BAL-AZ-06Simvastatin Left Lung -
SA046834BAL-AZ-11Simvastatin Left Lung -
SA046835BAL-AZ-05Simvastatin Left Lung 12
SA046836BAL-AZ-35Simvastatin Left Lung 12
SA046837BAL-AZ-25Simvastatin Left Lung 12
SA046838BAL-AZ-23Simvastatin Left Lung 8
SA046839BAL-AZ-28Simvastatin Left Lung 8
SA046840BAL-AZ-08Simvastatin Left Lung 8
SA046841BAL-AZ-30Simvastatin Right Lung -
SA046842BAL-AZ-27Simvastatin Right Lung -
SA046843BAL-AZ-03Simvastatin Right Lung -
SA046844BAL-AZ-21Simvastatin Right Lung 12
SA046845BAL-AZ-31Simvastatin Right Lung 12
SA046846BAL-AZ-20Simvastatin Right Lung 12
SA046847BAL-AZ-32Simvastatin Right Lung 8
SA046848BAL-AZ-29Simvastatin Right Lung 8
SA046849BAL-AZ-15Simvastatin Right Lung 8
Showing results 1 to 67 of 67
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