Summary of Study ST000899

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000625. The data can be accessed directly via it's Project DOI: 10.21228/M8W983 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000899
Study TitleAlterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling
Study SummaryNon-invasive biomarkers are needed in inflammatory bowel disease (IBD) to help define disease activity and identify underlying pathogenic mechanisms. We hypothesized that serum metabolomics, which produces unique metabolite profiles, can aid in this search. The aim of this study was to characterize serum metabolomic profiles in patients with IBD, and to assess for differences between patients with ulcerative colitis (UC), Crohn disease (CD), and non-IBD subjects. Serum samples from 20 UC, 20 CD, and 20 non-IBD control subjects were obtained along with patient characteristics, including medication use and clinical disease activity. Non-targeted metabolomic profiling was performed using ultra-high performance liquid chromatography/mass spectrometry (UPLC-MS/MS) optimized for basic or acidic species and hydrophilic interaction liquid chromatography (HILIC/UPLC-MS/MS).
Institute
Vanderbilt University Medical Center
Last NameScoville
First NameElizabeth
Address1030C MRB IV, 2215 Garland Avenue, Nashville, TN, 37232, USA
Emailelizabeth.a.scoville@vanderbilt.edu
Phone615-322-5200
Submit Date2017-08-29
Publicationshttps://doi.org/10.1007/s11306-017-1311-y
Analysis Type DetailLC-MS
Release Date2018-01-11
Release Version1
Elizabeth Scoville Elizabeth Scoville
https://dx.doi.org/10.21228/M8W983
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human serum; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Type
SA05281279Control
SA05281375Control
SA05281473Control
SA05281569Control
SA05281686Control
SA052817121Control
SA0528184Control
SA05281922Control
SA052820144Control
SA05282167Control
SA05282276Control
SA05282343Control
SA05282427Control
SA05282559Control
SA05282650Control
SA05282749Control
SA05282854Control
SA05282951Control
SA05283052Control
SA05283125Control
SA052832318Crohn disease
SA052833321Crohn disease
SA052834324Crohn disease
SA052835313Crohn disease
SA052836303Crohn disease
SA052837327Crohn disease
SA052838305Crohn disease
SA052839306Crohn disease
SA052840309Crohn disease
SA052841310Crohn disease
SA052842304Crohn disease
SA052843342Crohn disease
SA052844345Crohn disease
SA052845347Crohn disease
SA052846341Crohn disease
SA052847337Crohn disease
SA052848330Crohn disease
SA052849333Crohn disease
SA052850335Crohn disease
SA052851329Crohn disease
SA05285288Ulcerative Colitis
SA05285363Ulcerative Colitis
SA05285468Ulcerative Colitis
SA05285571Ulcerative Colitis
SA05285656Ulcerative Colitis
SA05285748Ulcerative Colitis
SA05285812Ulcerative Colitis
SA05285918Ulcerative Colitis
SA05286035Ulcerative Colitis
SA05286177Ulcerative Colitis
SA05286280Ulcerative Colitis
SA052863157Ulcerative Colitis
SA052864168Ulcerative Colitis
SA052865194Ulcerative Colitis
SA052866143Ulcerative Colitis
SA052867130Ulcerative Colitis
SA05286890Ulcerative Colitis
SA05286991Ulcerative Colitis
SA052870125Ulcerative Colitis
SA052871197Ulcerative Colitis
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