Summary of Study ST000947

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000652. The data can be accessed directly via it's Project DOI: 10.21228/M8D38P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST000947
Study TitleMechanisms for Insulin Resistance in Polycystic Ovary Syndrome with metformin therapy: aminoadipic acid, lysine concentrations, and enrichment (part I)
Study SummaryTo determine whether altered lysine and α-aminoadipic acid (AAA) kinetics explain previous observations of increased lysine and AAA concentrations in PCOS compared to controls, as measured by baseline lysine and AAA flux in PCOS versus healthy controls using [α-15N]-lysine and [13C]-AAA stable isotope tracers as well as by comparing the conversion of [α-15N]-lysine to [15N]-AAA. To evaluate how hyperinsulinemia affects lysine and AAA kinetics. Changes in lysine and AAA flux during a hyperinsulinemic-euglycemic clamp will be evaluated in healthy controls and compared to the baseline changes in lysine and AAA flux in PCOS. PCOS cases at baseline and after 3 months of metformin therapy.
Institute
Mayo Clinic
Last NameChang
First NameAl
Address200 First St. SW, Rochester, Minnesota, 55905, USA
EmailChang.Alice1@mayo.edu
Phone507-286-0505
Submit Date2018-04-09
Analysis Type DetailLC-MS
Release Date2020-04-13
Release Version1
Al Chang Al Chang
https://dx.doi.org/10.21228/M8D38P
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Time point Group
SA056607ms6188-7120 control
SA056608ms6102-7120 control
SA056609ms6182-7120 control
SA056610ms6036-7120 control
SA056611ms6034-7120 control
SA056612ms6032-7120 control
SA056613ms6185-7120 control
SA056614ms6243-7120 control
SA056615ms6035-7120 control
SA056616ms6184-7120 control
SA056617ms6183-7120 control
SA056594ms6099-7120 PCOS
SA056595ms6042-7120 PCOS
SA056596ms6098-7120 PCOS
SA056597ms6039-7120 PCOS
SA056598ms6187-7120 PCOS
SA056599ms6189-7120 PCOS
SA056600ms6186-7120 PCOS
SA056601ms6087-7120 PCOS
SA056602ms6091-7120 PCOS
SA056603ms6101-7120 PCOS
SA056604ms6100-7120 PCOS
SA056605ms6038-7120 PCOS
SA056606ms6275-7120 PCOS
SA056631ms6034-8135 control
SA056632ms6036-8135 control
SA056633ms6182-8135 control
SA056634ms6102-8135 control
SA056635ms6243-8135 control
SA056636ms6183-8135 control
SA056637ms6188-8135 control
SA056638ms6035-8135 control
SA056639ms6185-8135 control
SA056640ms6184-8135 control
SA056641ms6032-8135 control
SA056618ms6099-8135 PCOS
SA056619ms6100-8135 PCOS
SA056620ms6098-8135 PCOS
SA056621ms6187-8135 PCOS
SA056622ms6042-8135 PCOS
SA056623ms6087-8135 PCOS
SA056624ms6091-8135 PCOS
SA056625ms6275-8135 PCOS
SA056626ms6101-8135 PCOS
SA056627ms6186-8135 PCOS
SA056628ms6189-8135 PCOS
SA056629ms6038-8135 PCOS
SA056630ms6039-8135 PCOS
SA056655ms6183-9150 control
SA056656ms6035-9150 control
SA056657ms6032-9150 control
SA056658ms6182-9150 control
SA056659ms6243-9150 control
SA056660ms6185-9150 control
SA056661ms6102-9150 control
SA056662ms6036-9150 control
SA056663ms6188-9150 control
SA056664ms6184-9150 control
SA056665ms6034-9150 control
SA056642ms6101-9150 PCOS
SA056643ms6099-9150 PCOS
SA056644ms6039-9150 PCOS
SA056645ms6098-9150 PCOS
SA056646ms6038-9150 PCOS
SA056647ms6187-9150 PCOS
SA056648ms6087-9150 PCOS
SA056649ms6189-9150 PCOS
SA056650ms6091-9150 PCOS
SA056651ms6042-9150 PCOS
SA056652ms6275-9150 PCOS
SA056653ms6186-9150 PCOS
SA056654ms6100-9150 PCOS
SA056511ms6188-5-15 control
SA056512ms6102-5-15 control
SA056513ms6243-5-15 control
SA056514ms6185-5-15 control
SA056515ms6036-5-15 control
SA056516ms6182-5-15 control
SA056517ms6035-5-15 control
SA056518ms6184-5-15 control
SA056519ms6183-5-15 control
SA056520ms6034-5-15 control
SA056521ms6032-5-15 control
SA056498ms6039-5-15 PCOS
SA056499ms6275-5-15 PCOS
SA056500ms6187-5-15 PCOS
SA056501ms6098-5-15 PCOS
SA056502ms6091-5-15 PCOS
SA056503ms6087-5-15 PCOS
SA056504ms6038-5-15 PCOS
SA056505ms6186-5-15 PCOS
SA056506ms6042-5-15 PCOS
SA056507ms6099-5-15 PCOS
SA056508ms6100-5-15 PCOS
SA056509ms6101-5-15 PCOS
SA056510ms6189-5-15 PCOS
SA056679ms6185-10165 control
SA056680ms6032-10165 control
SA056681ms6035-10165 control
SA056682ms6184-10165 control
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