Summary of Study ST001039

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000679. The data can be accessed directly via it's Project DOI: 10.21228/M8X10M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001039
Study TitleDenver Asthma Panel Study-CHEAR Ancillary Study (part II)
Study SummaryUrban environments remain a poorly understood toxic environment for children with asthma, where improved exposure characterization and estimation of exposurehealth outcome relationships are clearly needed. The goal of this project is to investigate the interactions between relevant environmental exposures and asthma severity in a year-long longitudinal study of urban children with asthma. Environmental and clinical samples are being collected at 3 seasonal visits. Using these samples, we will measure the effects of multiple relevant exposures (environmental tobacco smoke (ETS), polycyclic aromatic hydrocarbons (PAHs), phthalates, and volatile organic compounds (VOCs)) on biological responses (metabolomics, oxidative stress, inflammatory markers, and endocannabinoids) and asthma outcomes. Our overall hypothesis is that relevant environmental exposures and their interactions drive disease severity in urban children with asthma. We will test this hypothesis by investigating the following aims: Aim 1: To investigate how environmental exposures (ETS, PAHs, phthalates, and VOCs) and their interactions contribute to asthma severity in urban children. Aim 2: To determine if environmental exposures in children with asthma are associated with changes in in biological responses (metabolomics, oxidative stress, inflammatory markers, and endocannabinoids). Aim 3: To determine which biological responses mediate the relationships between environmental exposures and asthma severity. Aim 4: To compare environmental exposures and biological responses in asthmatic and non-asthmatic children
Institute
Emory University
DepartmentSchool of Medicine
LaboratoryClincal Biomarkers Laboratory
Last NameUppal
First NameKaran
Address615 Michael St. Ste 225, Atlanta, GA, 30322, USA
Emailkuppal2@emory.edu
Phone(404) 727 5027
Submit Date2018-07-12
Total Subjects169
Study CommentsBoth CHEAR pooled urine samples and Clinical Biomarker Laboratory pooled plasma samples were used
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Karan Uppal Karan Uppal
https://dx.doi.org/10.21228/M8X10M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Urine samples; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample.Matrix
SA070572Q-Std Plasma pool_4b_1Plasma
SA070573NIST SRM 1950_1bPlasma
SA070574NIST SRM 1950_1aPlasma
SA070575Q-Std Plasma pool_4a_1Plasma
SA070576Q-Std Plasma pool_3a_1Plasma
SA070577Q-Std Plasma pool_2a_1Plasma
SA070578Q-Std Plasma pool_2b_1Plasma
SA070579Q-Std Plasma pool_1a_2Plasma
SA070580Q-Std Plasma pool_3b_1Plasma
SA070581Q-Std Plasma pool_1b_2Plasma
SA070582Q-Std Plasma pool_4a_2Plasma
SA070583Q-Std Plasma pool_4b_2Plasma
SA070584NIST SRM 1950_2bPlasma
SA070585Q-Std Plasma pool_3b_2Plasma
SA070586Q-Std Plasma pool_3a_2Plasma
SA070587Q-Std Plasma pool_2a_2Plasma
SA070588Q-Std Plasma pool_2b_2Plasma
SA070589Q-Std Plasma pool_1b_1Plasma
SA070590NIST SRM 1950_2aPlasma
SA070591Q-Std Plasma pool_1a_1Plasma
SA070592chearurine_2c_2Urine
SA070593chearurine_2d_2Urine
SA070594C-1G2Q5-U-04_2Urine
SA070595C-1G4D1-U-03_2Urine
SA070596C-1G9T1-U-00_2Urine
SA070597C-1GB27-U-00_2Urine
SA070598C-1G660-U-02_2Urine
SA070599C-1G389-U-04_2Urine
SA070600C-1G2L6-U-03_2Urine
SA070601C-1G8D7-U-03_2Urine
SA070602C-1G3U5-U-01_2Urine
SA070603C-1GAL1-U-04_2Urine
SA070604C-1GB50-U-00_2Urine
SA070605C-1GA77-U-01_2Urine
SA070606C-1FXP1-U-02_2Urine
SA070607C-1G0T0-U-00_2Urine
SA070608C-1FY18-U-02_2Urine
SA070609C-1FZN3-U-00_2Urine
SA070610C-1G2V4-U-04_2Urine
SA070611C-1GAY2-U-00_2Urine
SA070612C-1G7Y2-U-04_2Urine
SA070613C-1G5Y4-U-00_2Urine
SA070614C-1G314-U-02_2Urine
SA070615C-1G8G1-U-04_2Urine
SA070616C-1G5M1-U-00_2Urine
SA070617chearurine_2f_2Urine
SA070618chearurine_2e_2Urine
SA070619C-1G322-U-03_2Urine
SA070620C-1G603-U-00_2Urine
SA070621C-1FXK2-U-00_1Urine
SA070622C-1GAM9-U-02_1Urine
SA070623C-1G5W9-U-01_2Urine
SA070624C-1G2K8-U-00_2Urine
SA070625chearurine_3b_2Urine
SA070626chearurine_3a_2Urine
SA070627C-1G1L7-U-00_2Urine
SA070628C-1FWY2-U-00_2Urine
SA070629C-1G1M5-U-02_2Urine
SA070630C-1G520-U-04_2Urine
SA070631C-1G4L4-U-02_2Urine
SA070632C-1G4U4-U-01_2Urine
SA070633C-1GB43-U-03_2Urine
SA070634C-1G2A0-U-03_2Urine
SA070635C-1FZH7-U-00_2Urine
SA070636C-1G5C3-U-02_2Urine
SA070637C-1G4Y5-U-00_2Urine
SA070638C-1FY26-U-04_2Urine
SA070639C-1G0U8-U-02_2Urine
SA070640C-1G3F8-U-00_2Urine
SA070641C-1FY42-U-01_2Urine
SA070642chearurine_1d_2Urine
SA070643chearurine_1c_2Urine
SA070644C-1G5U3-U-03_2Urine
SA070645C-1G1S1-U-02_2Urine
SA070646C-1G5X6-U-01_2Urine
SA070647C-1G2A0-U-04_2Urine
SA070648C-1G546-U-02_2Urine
SA070649C-1G3X8-U-00_2Urine
SA070650C-1G520-U-02_2Urine
SA070651C-1G2M4-U-00_2Urine
SA070652C-1G2Q5-U-00_2Urine
SA070653C-1G1K9-U-00_2Urine
SA070654C-1G082-U-00_2Urine
SA070655C-1G3H4-U-01_2Urine
SA070656C-1G918-U-01_2Urine
SA070657C-1FYV7-U-02_2Urine
SA070658C-1G7X4-U-01_2Urine
SA070659C-1G7V9-U-00_2Urine
SA070660C-1FXA4-U-04_2Urine
SA070661C-1FZE3-U-04_2Urine
SA070662C-1G7W7-U-03_2Urine
SA070663C-1FY42-U-03_2Urine
SA070664C-1G1T9-U-02_2Urine
SA070665C-1GAN6-U-00_1Urine
SA070666C-1GAS5-U-04_1Urine
SA070667chearurine_1f_2Urine
SA070668chearurine_1e_2Urine
SA070669chearurine_2a_2Urine
SA070670chearurine_2b_2Urine
SA070671C-1FZ33-U-01_2Urine
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