Summary of Study ST001235
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000828. The data can be accessed directly via it's Project DOI: 10.21228/M8NQ4J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001235 |
| Study Title | Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part I |
| Study Summary | Inhibition of immune-checkpoint targets including PD1 is clinically effective in a variety of cancers. However, only a subset of patients respond and complete response remains uncommon. Given the known role of metabolites in modulating immunity, we sought to understand how individual patients’ metabolic activities adapt to PD1 immune checkpoint blockade and how they associate with therapeutic benefits. To this end, we profiled metabolites in pre- and multiple on-treatment patient serum samples from three independent immunotherapy trials using hydrophilic interaction liquid chromatography coupled with either triple quadrupole MS multiple reaction monitoring or high resolution full scan MS detection. The study consisted of two Phase I trials (CA209-038, NCT01621490; CA209-009, NCT01358721) which included 78 patients with advanced melanoma and 91 patients with metastatic renal cell carcinoma (RCC) treated with nivolumab. To investigate the generalizability of our results, we also analyzed a large randomized Phase III trial (CheckMate 025, NCT01668784) with 743 RCC patients, among which 394 received nivolumab and 349 received everolimus. |
| Institute | Broad Institute of MIT and Harvard |
| Last Name | Clish |
| First Name | Clary |
| Address | 415 Main St, Cambridge, MA 02142 |
| clary@broadinstitute.org | |
| Phone | 617-714-7654 |
| Submit Date | 2019-08-08 |
| Num Groups | 1 |
| Total Subjects | 78 |
| Num Males | 44 |
| Num Females | 34 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2019-08-27 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | Time point | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS) |
|---|---|---|---|
| SA088208 | CA209038-3-66_baseline | baseline | - |
| SA088209 | CA209038-6-62_baseline | baseline | - |
| SA088210 | CA209038-7-70_baseline | baseline | - |
| SA088211 | CA209038-9-74_baseline | baseline | - |
| SA088212 | CA209038-3-76_baseline | baseline | - |
| SA088213 | CA209038-1-59_baseline | baseline | - |
| SA088214 | CA209038-9-53_baseline | baseline | - |
| SA088215 | CA209038-9-46_baseline | baseline | - |
| SA088216 | CA209038-1-39_baseline | baseline | - |
| SA088217 | CA209038-4-47_baseline | baseline | - |
| SA088218 | CA209038-4-52_baseline | baseline | - |
| SA088219 | CA209038-5-77_baseline | baseline | - |
| SA088220 | CA209038-1-58_baseline | baseline | - |
| SA088221 | CA209038-5-79_baseline | baseline | - |
| SA088222 | CA209038-5-98_baseline | baseline | - |
| SA088223 | CA209038-7-92_baseline | baseline | - |
| SA088224 | CA209038-5-100_baseline | baseline | - |
| SA088225 | CA209038-13-106_baseline | baseline | - |
| SA088226 | CA209038-1-1_baseline | baseline | - |
| SA088227 | CA209038-7-90_baseline | baseline | - |
| SA088228 | CA209038-6-86_baseline | baseline | - |
| SA088229 | CA209038-7-80_baseline | baseline | - |
| SA088230 | CA209038-3-81_baseline | baseline | - |
| SA088231 | CA209038-1-82_baseline | baseline | - |
| SA088232 | CA209038-5-84_baseline | baseline | - |
| SA088233 | CA209038-8-38_baseline | baseline | - |
| SA088234 | CA209038-3-89_baseline | baseline | - |
| SA088235 | CA209038-12-11_baseline | baseline | - |
| SA088236 | CA209038-8-10_baseline | baseline | - |
| SA088237 | CA209038-12-28_baseline | baseline | - |
| SA088238 | CA209038-8-17_baseline | baseline | - |
| SA088239 | CA209038-10-27_baseline | baseline | - |
| SA088240 | CA209038-12-13_baseline | baseline | - |
| SA088241 | CA209038-12-16_baseline | baseline | - |
| SA088242 | CA209038-1-23_baseline | baseline | - |
| SA088243 | CA209038-8-25_baseline | baseline | - |
| SA088244 | CA209038-12-14_baseline | baseline | - |
| SA088245 | CA209038-8-9_baseline | baseline | - |
| SA088246 | CA209038-10-29_baseline | baseline | - |
| SA088247 | CA209038-14-35_baseline | baseline | - |
| SA088248 | CA209038-8-4_baseline | baseline | - |
| SA088249 | CA209038-8-5_baseline | baseline | - |
| SA088250 | CA209038-1-2_baseline | baseline | - |
| SA088251 | CA209038-9-37_baseline | baseline | - |
| SA088252 | CA209038-5-83_baseline | baseline | 1 |
| SA088253 | CA209038-8-3_baseline | baseline | 1 |
| SA088254 | CA209038-5-87_baseline | baseline | 1 |
| SA088255 | CA209038-6-104_baseline | baseline | 1 |
| SA088256 | CA209038-4-94_baseline | baseline | 1 |
| SA088257 | CA209038-3-101_baseline | baseline | 1 |
| SA088258 | CA209038-3-93_baseline | baseline | 1 |
| SA088259 | CA209038-6-102_baseline | baseline | 1 |
| SA088260 | CA209038-5-91_baseline | baseline | 1 |
| SA088261 | CA209038-7-103_baseline | baseline | 1 |
| SA088262 | CA209038-4-105_baseline | baseline | 1 |
| SA088263 | CA209038-4-108_baseline | baseline | 1 |
| SA088264 | CA209038-8-32_baseline | baseline | 1 |
| SA088265 | CA209038-9-54_baseline | baseline | 1 |
| SA088266 | CA209038-10-31_baseline | baseline | 1 |
| SA088267 | CA209038-10-30_baseline | baseline | 1 |
| SA088268 | CA209038-14-34_baseline | baseline | 1 |
| SA088269 | CA209038-1-51_baseline | baseline | 1 |
| SA088270 | CA209038-8-18_baseline | baseline | 1 |
| SA088271 | CA209038-12-44_baseline | baseline | 1 |
| SA088272 | CA209038-9-36_baseline | baseline | 1 |
| SA088273 | CA209038-8-48_baseline | baseline | 1 |
| SA088274 | CA209038-5-60_baseline | baseline | 1 |
| SA088275 | CA209038-3-49_baseline | baseline | 1 |
| SA088276 | CA209038-1-71_baseline | baseline | 1 |
| SA088277 | CA209038-1-73_baseline | baseline | 1 |
| SA088278 | CA209038-10-24_baseline | baseline | 1 |
| SA088279 | CA209038-6-63_baseline | baseline | 1 |
| SA088280 | CA209038-12-26_baseline | baseline | 1 |
| SA088281 | CA209038-6-69_baseline | baseline | 1 |
| SA088282 | CA209038-6-68_baseline | baseline | 1 |
| SA088283 | CA209038-6-64_baseline | baseline | 1 |
| SA088284 | CA209038-4-67_baseline | baseline | 1 |
| SA088285 | CA209038-9-46_week 4 | week 4 | - |
| SA088286 | CA209038-4-47_week 4 | week 4 | - |
| SA088287 | CA209038-7-70_week 4 | week 4 | - |
| SA088288 | CA209038-9-37_week 4 | week 4 | - |
| SA088289 | CA209038-14-35_week 4 | week 4 | - |
| SA088290 | CA209038-5-98_week 4 | week 4 | - |
| SA088291 | CA209038-5-84_week 4 | week 4 | - |
| SA088292 | CA209038-8-38_week 4 | week 4 | - |
| SA088293 | CA209038-1-59_week 4 | week 4 | - |
| SA088294 | CA209038-3-89_week 4 | week 4 | - |
| SA088295 | CA209038-5-100_week 4 | week 4 | - |
| SA088296 | CA209038-6-86_week 4 | week 4 | - |
| SA088297 | CA209038-6-62_week 4 | week 4 | - |
| SA088298 | CA209038-7-90_week 4 | week 4 | - |
| SA088299 | CA209038-4-52_week 4 | week 4 | - |
| SA088300 | CA209038-1-58_week 4 | week 4 | - |
| SA088301 | CA209038-7-92_week 4 | week 4 | - |
| SA088302 | CA209038-8-17_week 4 | week 4 | - |
| SA088303 | CA209038-8-9_week 4 | week 4 | - |
| SA088304 | CA209038-8-10_week 4 | week 4 | - |
| SA088305 | CA209038-12-11_week 4 | week 4 | - |
| SA088306 | CA209038-8-5_week 4 | week 4 | - |
| SA088307 | CA209038-8-4_week 4 | week 4 | - |
