Summary of Study ST001397

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000952. The data can be accessed directly via it's Project DOI: 10.21228/M8N397 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001397
Study TitleQuantitative Hexose study on total murine liver tissue from mice at different age
Study TypeLiver tissue/Primary tissue
Study SummaryFollowing birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, the liver undergoes functional transition from a hematopoietic organ to a central organ of metabolic regulation and immune surveillance. The aim of the present study was to analyze the influence of the developing hepatic function and liver metabolism on the early intestinal microbiota. Using metabolomic and microbial profiling in combination with multivariate analysis we characterized the colonization dynamics and liver metabolism in the murine gastrointestinal tract (n=6-10 per age group). We observed major age-dependent microbial and metabolic changes and identified bile acids as potent drivers of the early intestinal microbiota maturation. Consistently, oral administration of tauro-cholic acid or β-tauro-murocholic acid to newborn mice (n= 7-14 per group) accelerated postnatal microbiota maturation.Summed hexoses in total liver tissue from healthy C57BL/6 mice at 1, 7, 14, 21, 28 and 56 day after birth was analyzed.
Institute
Helmholtz Centre for Environmental Research
DepartmentDepartment of Molecular Systems biology
LaboratoryFunctional Metabolomics
Last NameRolle-Kampczyk
First NameUlrike
AddressPermoserstrasse 15, 04318 Leipzig, Germany
Emailulrike.rolle-kampczyk@ufz.de
Phone0049 341 235 1537
Submit Date2020-06-03
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2020-06-10
Release Version1
Ulrike Rolle-Kampczyk Ulrike Rolle-Kampczyk
https://dx.doi.org/10.21228/M8N397
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Litter Day after birth
SA113540L_K10D1_neg10 1
SA113541L_K10D14_neg10 14
SA113542L_K10D21_neg10 21
SA113543L_K10D28_neg10 28
SA113544L_K10D56_neg10 56
SA113545L_K10D7_neg10 7
SA113546L_K11D1_neg11 1
SA113547L_K11D14_neg11 14
SA113548L_K11D21_neg11 21
SA113549L_K11D28_neg11 28
SA113550L_K11D56_neg11 56
SA113551L_K11D7_neg11 7
SA113552L_K7D14_neg7 14
SA113553L_K7D21_neg7 21
SA113554L_K7D28_neg7 28
SA113555L_K7D56_neg7 56
SA113556L_K7D7_neg7 7
SA113557L_K8D14_neg8 14
SA113558L_K8D21_neg8 21
SA113559L_K8D28_neg8 28
SA113560L_K8D56_neg8 56
SA113561L_K8D7_neg8 7
SA113562L_K9D1_neg9 1
SA113563L_K9D14_neg9 14
SA113564L_K9D21_neg9 21
SA113565L_K9D28_neg9 28
SA113566L_K9D56_neg9 56
SA113567L_K9D7_neg9 7
Showing results 1 to 28 of 28
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