Summary of study ST001652

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001058. The data can be accessed directly via it's Project DOI: 10.21228/M8XX2B This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001652
Study TitleAtypical Molecular Basis for Drug Resistance to Mitochondrial AQ: A Function Inhibitors in Plasmodium falciparum
Study SummaryIn this study, we present a clear genotype for the P. falciparum SB1-A6 acridone-resistant clonal parasite strain and, through a combination of targeted and whole-cell methods, establish that the mechanism of resistance to both cytochrome bc1 and DHODH inhibitors results from the contribution of multiple genetic polymorphisms. We find that P. falciparum SB1-A6 accumulates both a copy number variation and a specific mutation in PfDHODH, and both of these genetic polymorphisms contribute to the panresistant phenotype. This study uncovers a mechanism of cross-resistance between PfDHODH and mtETC inhibitors and serves as a cautionary note to future antimalarial combination therapy formulations containing such drugs.
U.S. Food & Drug Administration
Last NamePainter
First NameHeather
Address10903 New Hampshire Ave., WO 52/72-5324, Silver Spring, MD 20993
Submit Date2021-01-17
Raw Data AvailableYes
Raw Data File Type(s).mzXML
Analysis Type DetailLC-MS
Release Date2021-02-01
Release Version1
Heather Painter Heather Painter application/zip

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Subject type: Cultured cells; Subject species: Plasmodium falciparum (Factor headings shown in green)

mb_sample_id local_sample_id Genotype Treatment
SA1517319_A6_AT1Drug Resistant Atovaquone
SA15173219_A6_AT2Drug Resistant Atovaquone
SA15173328_A6_AT3Drug Resistant Atovaquone
SA15173431_A6_CT3Drug Resistant Control
SA15173521_A6_CT2Drug Resistant Control
SA1517367_A6_CT1Drug Resistant Control
SA1517378_A6_DT1Drug Resistant DSM-1
SA15173820_A6_DT2Drug Resistant DSM-1
SA15173926_A6_DT3Drug Resistant DSM-1
SA15174017_D6_DT2Drug Resistant DSM-1
SA15174112_D6_AT1Wild-type Atovaquone
SA15174216_D6_AT2Wild-type Atovaquone
SA15174325_D6_AT3Wild-type Atovaquone
SA15174410_D6_CT1Wild-type Control
SA15174529_D6_CT3Wild-type Control
SA15174618_D6_CT2Wild-type Control
SA15174711_D6_DT1Wild-type DSM-1
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