Summary of study ST001702

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001089. The data can be accessed directly via it's Project DOI: 10.21228/M8XT42 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001702
Study TitleA cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Heart) part-IV
Study SummaryAging is associated with distinct phenotypical, physiological, and functional changes, leading to the onset of disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we performed physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that the decline in gait speed as a function of age and frailty is associated with dramatic increases in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their substrate selection and metabolism towards redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual and organ levels.
Institute
National Institutes of Health
DepartmentNIA
LaboratoryExperimental Gerontology Section and Translational Gerontology Branch
Last Namede Cabo
First NameRafael
Address251 Bayview Blvd. Suite 100/Room 5C214. Baltimore, MD 21224
EmaildeCaboRa@grc.nia.nih.gov
Phone1-410-558-8510
Submit Date2021-02-11
Raw Data AvailableYes
Raw Data File Type(s).cdf
Analysis Type DetailGC-MS
Release Date2021-03-01
Release Version1
Rafael de Cabo Rafael de Cabo
https://dx.doi.org/10.21228/M8XT42
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Age
SA15827414_heart_014mid age
SA15827530_heart_030mid age
SA15827619_heart_019mid age
SA1582774_heart_004mid age
SA1582785_heart_005mid age
SA15827910_heart_010mid age
SA15828012_heart_012mid age
SA15828111_heart_011old
SA15828215_heart_015old
SA15828329_heart_029old
SA15828428_heart_028old
SA15828520_heart_020old
SA1582866_heart_006old
SA1582873_heart_003old
SA1582882_heart_002old
SA1582898_heart_008old
SA1582909_heart_009old
SA15829127_heart_027old
SA15829223_heart_023young
SA15829324_heart_024young
SA15829425_heart_025young
SA15829522_heart_022young
SA15829616_heart_016young
SA15829713_heart_013young
SA15829826_heart_026young
SA15829918_heart_018young
SA1583001_heart_001young
SA15830121_heart_021young
SA15830217_heart_017young
SA1583037_heart_007young
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