Summary of Study ST001842

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000667. The data can be accessed directly via it's Project DOI: 10.21228/M8FX07 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001842
Study TitleIdentification of unique metabolite networks between Latino and Caucasian patients with nonalcoholic fatty liver disease (NAFLD) (part I)
Study SummaryNonalcoholic fatty liver disease (NAFLD) is a spectrum of liver pathology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH); the latter is characterized by inflammation and fibrosis. Risk factors for NALFD include obesity, diabetes, hyperlipidemia, and hypertension—all of which are features of metabolic syndrome. NAFLD is a very heterogeneous disease, as it presents in different patterns in males and females and in patients from different ethnicities, with unclear predictors for development and severity of disease. Previous studies have shown that NAFLD is 1.4 times more frequent in Hispanics than in Caucasians. One of the major challenges in NAFLD is the lack of accurate, noninvasive biomarkers for the detection of the most aggressive presentation, NASH. The gold standard for the diagnosis is liver biopsy, which is an invasive procedure associated with possible complications. Noninvasive diagnosis of NASH is a major unmet medical need and there are no ethnicity-specific biomarkers that can diagnose this condition and predict its progression. Therefore, the main gap in knowledge that this proposal and line of research will address is the characterizing the different plasma and liver metabolomics profile of patients with fatty liver from two ethnicities (Latinos vs. Caucasians) and of both sexes. The overall hypothesis of the present study is that the higher incidence of nonalcoholic fatty liver (NAFL) in Latino patients is reflected in a different plasma and liver metabolomics profile compared to Caucasian patients with further sex-related differences. Characterization of metabolite networks can aid in identifying the mechanistic underpinnings of sex and ethnic driven differences in NAFL which could help diagnose and establish a prognosis of this condition, especially in the critical transition from NAFL to the more aggressive nonalcoholic steatohepatitis (NASH).To address this hypothesis, plasma metabolomics profile of samples from male and female Latino and Caucasian bariatric surgery patients with NAFL and from healthy subjects will be compared. Metabolomics findings will be related with liver pathology and liver transcriptome profiles from intraoperatively obtained liver biopsies using correlation, network, and pathway analysis.
Institute
University of California, Davis
DepartmentDepartment of Internal Medicine, Division of Gastroenterology and Hepatology
LaboratoryMedici Lab
Last NameMedici
First NameValentina
Address4150 V Street - PSSB Suite 3500 - 95817 Sacramento CA
Emailvmedici@ucdavis.edu
Phone(916) 734 3751
Submit Date2021-06-10
Raw Data AvailableYes
Raw Data File Type(s)cdf
Analysis Type DetailGC-MS
Release Date2021-07-05
Release Version1
Valentina Medici Valentina Medici
https://dx.doi.org/10.21228/M8FX07
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Diagnosis Ethnicity Organ
SA171464HC126_033Healthy Control Caucasian plasma
SA171465M2_035Healthy Control Caucasian plasma
SA171466K9_038Healthy Control Caucasian plasma
SA171467HC105_037Healthy Control Caucasian plasma
SA171468HC117_032Healthy Control Caucasian plasma
SA171469HC121_036Healthy Control Caucasian plasma
SA171470HC122_034Healthy Control Caucasian plasma
SA171471K10_039Healthy Control Caucasian plasma
SA1714722_019Healthy Control Hispanic plasma
SA171473236_028Healthy Control Hispanic plasma
SA171474151_024Healthy Control Hispanic plasma
SA171475HC128_040Healthy Control Hispanic plasma
SA17147610_020Healthy Control Hispanic plasma
SA171477316_029Healthy Control Hispanic plasma
SA17147880_022Healthy Control Hispanic plasma
SA171479175_025Healthy Control Hispanic plasma
SA171480110_023Healthy Control Hispanic plasma
SA171481204_027Healthy Control Hispanic plasma
SA171482343_030Healthy Control Hispanic plasma
SA171483197_026Healthy Control Hispanic plasma
SA171484HC127_031Healthy Control Hispanic plasma
SA17148526_021Healthy Control Hispanic plasma
SA171486B-1342_050NAFLD Caucasian liver
SA171487BSU-0197_043NAFLD Caucasian liver
SA171488BSU-0187_046NAFLD Caucasian liver
SA171489B-1297_041NAFLD Caucasian liver
SA171490B-0286_044NAFLD Caucasian liver
SA171491B-0254_048NAFLD Caucasian liver
SA171492BSU-0146_042NAFLD Caucasian liver
SA171493B-1513_047NAFLD Caucasian liver
SA171494B-1441_049NAFLD Caucasian liver
SA171495B-1501_045NAFLD Caucasian liver
SA171496P-0432_003NAFLD Caucasian plasma
SA171497P-3194_001NAFLD Caucasian plasma
SA171498P-3266_007NAFLD Caucasian plasma
SA171499P-0185_002NAFLD Caucasian plasma
SA171500P-1006_004NAFLD Caucasian plasma
SA171501P-3182_008NAFLD Caucasian plasma
SA171502P-0788_006NAFLD Caucasian plasma
SA171503P-0361_005NAFLD Caucasian plasma
SA171504B-1432_060NAFLD Hispanic liver
SA171505B-0269_057NAFLD Hispanic liver
SA171506B-1156_059NAFLD Hispanic liver
SA171507B-0945_053NAFLD Hispanic liver
SA171508B-0193_051NAFLD Hispanic liver
SA171509B-0262_052NAFLD Hispanic liver
SA171510B-1148_055NAFLD Hispanic liver
SA171511B-1184_054NAFLD Hispanic liver
SA171512B-1405_058NAFLD Hispanic liver
SA171513B-1371_056NAFLD Hispanic liver
SA171514P-3242_018NAFLD Hispanic plasma
SA171515P-3227_016NAFLD Hispanic plasma
SA171516P-2546_011NAFLD Hispanic plasma
SA171517P-3008_013NAFLD Hispanic plasma
SA171518P-0320_009NAFLD Hispanic plasma
SA171519P-3200_014NAFLD Hispanic plasma
SA171520P-3043_012NAFLD Hispanic plasma
SA171521P-1010_010NAFLD Hispanic plasma
SA171522P-3011_017NAFLD Hispanic plasma
SA171523P-0796_015NAFLD Hispanic plasma
Showing results 1 to 60 of 60
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