Summary of Study ST001916

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001208. The data can be accessed directly via it's Project DOI: 10.21228/M8JX2X This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001916
Study TitleMyocardial Rev-erb-mediated diurnal metabolic rhythm (Part 2/3)
Study SummaryAgonists and antagonists of nuclear receptor Rev-erbα/β, key components of the circadian clock, can benefit the heart. Here, we show that mice with cardiomyocyte-specific knockout (KO) of Rev-erbα/β display progressive cardiac dilation and lethal heart failure. Inducible ablation of Rev-erbα/β in adult hearts causes similar phenotypes. Impaired fatty acid oxidation in the KO myocardium, particularly in the light cycle, precedes contractile dysfunctions with a reciprocal overreliance on carbohydrate utilization, particularly in the dark cycle. These findings delineate temporal coordination between clock-mediated anticipation and nutrient-induced response in myocardial metabolism.
Institute
Baylor College of Medicine
Last NameSong
First NameShiyang
AddressOne Baylor Plaza,Houston, TX, 77030
Emailshiyangs@bcm.edu
Phone7137983159
Submit Date2021-09-10
Raw Data AvailableYes
Analysis Type DetailLC-MS
Release Date2022-12-24
Release Version1
Shiyang Song Shiyang Song
https://dx.doi.org/10.21228/M8JX2X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Group Genotype Experimental variables
SA177718KO_CD_3KO_CD Rev-erb cardiomyocyte specific knock out heart ventrcle harvest from KO mouse fed with chow diet
SA177719KO_CD_2KO_CD Rev-erb cardiomyocyte specific knock out heart ventrcle harvest from KO mouse fed with chow diet
SA177720KO_CD_1KO_CD Rev-erb cardiomyocyte specific knock out heart ventrcle harvest from KO mouse fed with chow diet
SA177715KO-HFHSD_2KO-HFHSD Rev-erb cardiomyocyte specific knock out heart ventrcle harvest from KOmouse fed with high fat high sucrose diet
SA177716KO-HFHSD_3KO-HFHSD Rev-erb cardiomyocyte specific knock out heart ventrcle harvest from KOmouse fed with high fat high sucrose diet
SA177717KO-HFHSD_1KO-HFHSD Rev-erb cardiomyocyte specific knock out heart ventrcle harvest from KOmouse fed with high fat high sucrose diet
SA177721WT_CD_2WT_CD wild type control heart ventrcle harvest from WT mouse fed with chow diet
SA177722WT_CD_3WT_CD wild type control heart ventrcle harvest from WT mouse fed with chow diet
SA177723WT_CD_1WT_CD wild type control heart ventrcle harvest from WT mouse fed with chow diet
SA177724WT_HFHSD_1WT_HFHSD wild type control heart ventrcle harvest from WT mouse fed with high fat high sucrose diet
SA177725WT_HFHSD_2WT_HFHSD wild type control heart ventrcle harvest from WT mouse fed with high fat high sucrose diet
SA177726WT_HFHSD_3WT_HFHSD wild type control heart ventrcle harvest from WT mouse fed with high fat high sucrose diet
Showing results 1 to 12 of 12
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