Summary of Study ST002047

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001294. The data can be accessed directly via it's Project DOI: 10.21228/M8FQ39 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST002047
Study TitleLyso-lipid induced oligodendrocytes maturation underlie restoration of optic nerve function
Study SummaryProtein hyper-deimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our in vitro studies show LPC 18:1 protection against neuron-ectopic hyper-deimination and stimulation of oligodendrocyte maturation, while in vivo investigations recorded optic nerve function improvement following optic nerve injections of LPC 18:1, in contrast to LPC 18:0. Thus just a change in a single bond renders a dramatic alternation in biological function. The incorporation of isobaric C13-histidine in newly synthesized myelin proteins and quantitative proteome shifts are consistent with remyelination underlying restoration in optic nerve function. These results suggest that exogenous LPC 18:1 may provide a therapeutic avenue for stemming vision loss in demyelinating diseases.
Institute
University of Miami
Last NameBhattacharya
First NameSanjoy K.
Address1638 NW 10th Avenue, Room 706-A, Miami, FL 33136
Emailsbhattacharya@med.miami.edu
Phone3054824103
Submit Date2021-12-16
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2022-01-21
Release Version1
Sanjoy K. Bhattacharya Sanjoy K. Bhattacharya
https://dx.doi.org/10.21228/M8FQ39
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Cultured cells; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id local_sample_id Factor
SA192475OLGO_PPOlig Over
SA192476OLGO_PP_20210319014845Olig Over
SA192477OLGO_PNOlig Over
SA192478OLGO_PN_20210318202010Olig Over
SA192479OLGO_NP_20210318175410Olig Over
SA192480OLGO_NPOlig Over
SA192481OLGO_NN_20210318164109Olig Over
SA192482Olig_NNP_3_20210317032612Olig siRNA
SA192483Olig_NPN_2Olig siRNA
SA192484Olig_NPN_2_20210317010010Olig siRNA
SA192485Olig_PNN_2Olig siRNA
SA192486Olig_NNP_3Olig siRNA
SA192487Olig_NNN_2Olig siRNA
SA192488Olig_PNN_2_20210317112047Olig siRNA
SA192489Olig_NNN_2_20210317100746Olig siRNA
SA192490Olig_NNP_2Olig siRNA
SA192491Olig_NNP_2_20210317074144Olig siRNA
SA192492Olig_PPP_2Olig siRNA
SA192493Olig_PPP_2_20210317043913Olig siRNA
SA192457OPCO_PNOPC Over
SA192458OPCO_PN_20210318232241OPC Over
SA192459OPCO_PP_20210318190709OPC Over
SA192460OPCO_NP_20210319003544OPC Over
SA192461OPCO_PPOPC Over
SA192462OPCO_NPOPC Over
SA192463OPCO_NNOPC Over
SA192464OPCO_NN_20210318220941OPC Over
SA192465OPC_PNN_1OPC siRNA
SA192466OPC_PNN_1_20210317134649OPC siRNA
SA192467OPC_NPN_1_20210317021311OPC siRNA
SA192468OPC_PPP_1OPC siRNA
SA192469OPC_NNP_1OPC siRNA
SA192470OPC_PPP_1_20210317055214OPC siRNA
SA192471OPC_NNN_1_20210317085445OPC siRNA
SA192472OPC_NNP_1_20210317123348OPC siRNA
SA192473OPC_NPN_1OPC siRNA
SA192474OPC_NNN_1OPC siRNA
SA192494RGC_over_NPRGC Over
SA192495RGC_over_PNRGC Over
SA192496repRGC_over_NNRGC Over
SA192497RGC_over_NNRGC Over
SA192498repRGC_over_PNRGC Over
SA192499repRGC_over_NPRGC Over
SA192500RGC_over_PPRGC Over
SA192501repRGC_over_PPRGC Over
SA192502RGC_si_PNNRGC siRNA
SA192503repRGC_si_NNNRGC siRNA
SA192504RGC_si_NNNRGC siRNA
SA192505RGC_si_NNPRGC siRNA
SA192506RGC_si_NPNRGC siRNA
SA192507repRGC_si_PPPRGC siRNA
SA192508repRGC_si_PNNRGC siRNA
SA192509repRGC_si_NNPRGC siRNA
SA192510repRGC_si_NPNRGC siRNA
SA192511RGC_si_PPPRGC siRNA
Showing results 1 to 55 of 55
  logo