Summary of Study ST002298

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001472. The data can be accessed directly via it's Project DOI: 10.21228/M8FT53 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002298
Study TitleNAD(P) deficiency plays an important role in the restraint-stress-induced depression in the rat model
Study SummaryThe metabolic dysfunction or irreversible metabolic changes from stress may cause body vulnerability, potentially leading to the onset of psychiatric and non-psychiatric illnesses. Nevertheless, little is known about the biochemical events that cause depression due to stress. Our study employed open field test, plasma adrenocorticotropic hormone (ACTH) and corticosterone determination, serum biochemical analysis, quantitative PCR, immunoblotting, enzyme activity assay, and NMR-based metabolomics to analyze and identify the biochemical variations of body fluids (serum and urine) and tissues (brain, kidney, liver, lung, and spleen) in an acute restraint stress-induced rat model of depression. Our data suggested that the post-stress effects on biochemical alterations involved different biochemical pathways, including regulating the NAD(P) pool, glucose homeostasis, biosynthesis and degradation of heme, and uric acid production and metabolism. The urinary excretion of nicotinate and nicotinamide N-oxide increased significantly. Thus, we conclude that the depletion of NAD(P) precursors may occur in response to restraint stress. Our results show a close association between NAD(P) deficiency and post-stress metabolic dysfunction, which would provide a ground for developing recovery-promoting micronutrients in treating depression.
Institute
Anhui Science and Technology University
Last NameLi
First NameJinquan
AddressNo. 9, Donghua Road, Fengyang, Anhui Province, 233100, China
Emaillijinquan@ahstu.edu.cn
Phone86 133 2875 1890
Submit Date2022-07-30
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2023-08-15
Release Version1
Jinquan Li Jinquan Li
https://dx.doi.org/10.21228/M8FT53
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id local_sample_id Experimental factor
SA220958urine_4431124 h post-stress
SA220959urine_4431224 h post-stress
SA220960urine_4431324 h post-stress
SA220961urine_4431024 h post-stress
SA220962urine_4430924 h post-stress
SA220963urine_4431424 h post-stress
SA220964urine_4430824 h post-stress
SA220965liver_4408448 h post-stress
SA220966liver_4407948 h post-stress
SA220967spleen_4410148 h post-stress
SA220968spleen_4409648 h post-stress
SA220969lung_4410748 h post-stress
SA220970lung_4410248 h post-stress
SA220971liver_4407448 h post-stress
SA220972lung_4409748 h post-stress
SA220973liver_4408948 h post-stress
SA220974liver_4409448 h post-stress
SA220975kidney_4408548 h post-stress
SA220976kidney_4408048 h post-stress
SA220977kidney_4409048 h post-stress
SA220978kidney_4409548 h post-stress
SA220979kidney_4410548 h post-stress
SA220980kidney_4410048 h post-stress
SA220981kidney_4407548 h post-stress
SA220982spleen_4410648 h post-stress
SA220983liver_4410448 h post-stress
SA220984liver_4409948 h post-stress
SA220985lung_4409248 h post-stress
SA220986lung_4408748 h post-stress
SA220987lung_4407748 h post-stress
SA220988lung_4408248 h post-stress
SA220989spleen_4407648 h post-stress
SA220990urine_4431848 h post-stress
SA220991serum_4401048 h post-stress
SA220992serum_4400948 h post-stress
SA220993serum_4401148 h post-stress
SA220994serum_4401248 h post-stress
SA220995serum_4401348 h post-stress
SA220996serum_4400848 h post-stress
SA220997serum_4400748 h post-stress
SA220998brain_4410848 h post-stress
SA220999brain_4410348 h post-stress
SA221000brain_4409848 h post-stress
SA221001brain_4409348 h post-stress
SA221002urine_4432148 h post-stress
SA221003brain_4408848 h post-stress
SA221004urine_4431648 h post-stress
SA221005urine_4431748 h post-stress
SA221006urine_4431948 h post-stress
SA221007urine_4432048 h post-stress
SA221008brain_4408348 h post-stress
SA221009urine_4431548 h post-stress
SA221010spleen_4409148 h post-stress
SA221011spleen_4408148 h post-stress
SA221012spleen_4408648 h post-stress
SA221013brain_4407848 h post-stress
SA221014lung_44052non-stress
SA221015lung_44057non-stress
SA221016lung_44047non-stress
SA221017brain_44053non-stress
SA221018brain_44063non-stress
SA221019brain_44068non-stress
SA221020brain_44073non-stress
SA221021brain_44058non-stress
SA221022brain_44048non-stress
SA221023lung_44067non-stress
SA221024lung_44072non-stress
SA221025lung_44062non-stress
SA221026kidney_44060non-stress
SA221027urine_44305non-stress
SA221028urine_44304non-stress
SA221029urine_44306non-stress
SA221030urine_44307non-stress
SA221031liver_44049non-stress
SA221032liver_44044non-stress
SA221033urine_44303non-stress
SA221034urine_44302non-stress
SA221035serum_44003non-stress
SA221036serum_44002non-stress
SA221037serum_44004non-stress
SA221038serum_44005non-stress
SA221039serum_44006non-stress
SA221040liver_44054non-stress
SA221041liver_44059non-stress
SA221042spleen_44046non-stress
SA221043kidney_44070non-stress
SA221044spleen_44051non-stress
SA221045spleen_44056non-stress
SA221046spleen_44066non-stress
SA221047spleen_44061non-stress
SA221048kidney_44065non-stress
SA221049serum_44001non-stress
SA221050liver_44069non-stress
SA221051liver_44064non-stress
SA221052kidney_44045non-stress
SA221053kidney_44050non-stress
SA221054kidney_44055non-stress
SA221055spleen_44071non-stress
Showing results 1 to 98 of 98
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