Summary of Study ST002420

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001558. The data can be accessed directly via it's Project DOI: 10.21228/M89M65 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002420
Study Title	Colorectal cancer isobaric labeling for metabolite quantification
Study Summary	A major challenge in reducing the death rate of colorectal cancer is to screen patients using low-invasive testing. Blood test shows a high compliance rate with reduced invasiveness. In this work, a multiplex isobaric tag labeling strategy coupled with mass spectrometry is adopted to relatively quantify primary and secondary amine-containing metabolites in serum for the discovery of metabolite biomarkers of colorectal cancer. Serum samples from patients at different risk statuses and colorectal cancer growth statuses are studied. Metabolite identification is based on accurate mass matching and/or retention time of labeled metabolite standards. We quantify 40 metabolites across all the serum samples, including 18 metabolites validated with standards. We find significantly decreased levels of threonine and asparagine in the patients with growing adenomas or high-risk adenomas (p < 0.05). Glutamine levels decrease in patients with adenomas of unknown growth status or high-risk adenomas. In contrast, arginine levels are elevated in patients with low-risk adenoma. Receiver operating characteristic analysis shows high sensitivity and specificity of these metabolites for detecting growing adenomas. Based on these results, we conclude that potential metabolite biomarkers identified here contribute to distinguishing colorectal patients with growing adenomas from normal individuals and patients with unknown growth status of adenomas.
Institute	University of Wisconsin - Madison
Last Name	Liu
First Name	Yuan
Address	777 Highland ave, Madison, Wisconsin, 53705, USA
Email	liu788@wisc.edu
Phone	6089606939
Submit Date	2022-12-28
Raw Data Available	Yes
Raw Data File Type(s)	mzML
Analysis Type Detail	LC-MS
Release Date	2023-03-31
Release Version	1

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id	local_sample_id	classification_based on growth rate	classification_based on risks
SA242323	N14	control	control
SA242324	N13	control	control
SA242325	N11	control	control
SA242326	N15	control	control
SA242327	N12	control	control
SA242328	N17	control	control
SA242329	N10	control	control
SA242330	N19	control	control
SA242331	N18	control	control
SA242332	N20	control	control
SA242333	N16	control	control
SA242334	N5	control	control
SA242335	N9	control	control
SA242336	N2	control	control
SA242337	N1	control	control
SA242338	N4	control	control
SA242339	N3	control	control
SA242340	N6	control	control
SA242341	N8	control	control
SA242342	N7	control	control
SA242281	23_pre	Growing	High‐risk
SA242282	23_post	Growing	High‐risk
SA242283	19_post	Growing	High‐risk
SA242284	19_pre	Growing	High‐risk
SA242285	15_post	Growing	High‐risk
SA242286	24_pre	Growing	High‐risk
SA242287	25_post	Growing	High‐risk
SA242288	33_pre	Growing	High‐risk
SA242289	33_post	Growing	High‐risk
SA242290	28_post	Growing	High‐risk
SA242291	28_pre	Growing	High‐risk
SA242292	15_pre	Growing	High‐risk
SA242293	25_pre	Growing	High‐risk
SA242294	24_post	Growing	High‐risk
SA242295	5_pre	Growing	High‐risk
SA242296	8_post	Growing	High‐risk
SA242297	5_post	Growing	High‐risk
SA242298	8_pre	Growing	High‐risk
SA242299	7_post	Growing	High‐risk
SA242300	7_pre	Growing	High‐risk
SA242343	2_post	growing	Low‐Risk
SA242344	2_pre	growing	Low‐Risk
SA242301	9_pre	Growing	Low‐Risk
SA242302	18_post	Growing	Low‐Risk
SA242303	32_post	Growing	Low‐Risk
SA242304	32_pre	Growing	Low‐Risk
SA242305	9_post	Growing	Low‐Risk
SA242306	18_pre	Growing	Low‐Risk
SA242345	20_post	static	High‐risk
SA242346	20_pre	static	High‐risk
SA242307	1_post	Static	Low‐Risk
SA242308	3_post	Static	Low‐Risk
SA242309	3_pre	Static	Low‐Risk
SA242310	1_pre	Static	Low‐Risk
SA242311	10_post	Unknown	High‐risk
SA242312	29_post	Unknown	High‐risk
SA242313	29_pre	Unknown	High‐risk
SA242314	12_post	Unknown	High‐risk
SA242315	12_pre	Unknown	High‐risk
SA242316	21_post	Unknown	High‐risk
SA242317	21_pre	Unknown	High‐risk
SA242318	10_pre	Unknown	High‐risk
SA242319	11_post	Unknown	Low‐Risk
SA242320	26_pre	Unknown	Low‐Risk
SA242321	26_post	Unknown	Low‐Risk
SA242322	11_pre	Unknown	Low‐Risk

Showing results 1 to 66 of 66

Showing results 1 to 66 of 66