Summary of Study ST002579

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002579
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Plasma - Targeted Amines
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Mayo Clinic
Department	Internal Medicine
Laboratory	Mayo Clinic Metabolomics Resource Core (MCMRC)
Last Name	Nair
First Name	K. Sreekumaran
Address	200 1st St SW, Rochester, MN 55902
Email	nair@mayo.edu
Phone	(507) 284-2511
Submit Date	2023-04-25
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA258849	90266013110	Control	8 weeks of training or control time	Female
SA258850	90245013110	Control	8 weeks of training or control time	Female
SA258851	90248013110	Control	8 weeks of training or control time	Female
SA258852	90265013110	Control	8 weeks of training or control time	Female
SA258853	90252013110	Control	8 weeks of training or control time	Female
SA258854	90239013110	Control	8 weeks of training or control time	Male
SA258855	90237013110	Control	8 weeks of training or control time	Male
SA258856	90229013110	Control	8 weeks of training or control time	Male
SA258857	90232013110	Control	8 weeks of training or control time	Male
SA258858	90217013110	Control	8 weeks of training or control time	Male
SA258859	90559013110	Training	1 week of training or control time	Female
SA258860	90560013110	Training	1 week of training or control time	Female
SA258861	90564013110	Training	1 week of training or control time	Female
SA258862	90567013110	Training	1 week of training or control time	Female
SA258863	90571013110	Training	1 week of training or control time	Female
SA258864	90430013110	Training	1 week of training or control time	Male
SA258865	90421013110	Training	1 week of training or control time	Male
SA258866	90423013110	Training	1 week of training or control time	Male
SA258867	90426013110	Training	1 week of training or control time	Male
SA258868	90422013110	Training	1 week of training or control time	Male
SA258869	90587013110	Training	2 weeks of training	Female
SA258870	90585013110	Training	2 weeks of training	Female
SA258871	90576013110	Training	2 weeks of training	Female
SA258872	90578013110	Training	2 weeks of training	Female
SA258873	90581013110	Training	2 weeks of training	Female
SA258874	90449013110	Training	2 weeks of training	Male
SA258875	90450013110	Training	2 weeks of training	Male
SA258876	90444013110	Training	2 weeks of training	Male
SA258877	90441013110	Training	2 weeks of training	Male
SA258878	90439013110	Training	2 weeks of training	Male
SA258879	90406013110	Training	4 weeks of training	Female
SA258880	90420013110	Training	4 weeks of training	Female
SA258881	90410013110	Training	4 weeks of training	Female
SA258882	90412013110	Training	4 weeks of training	Female
SA258883	90416013110	Training	4 weeks of training	Female
SA258884	90280013110	Training	4 weeks of training	Male
SA258885	90281013110	Training	4 weeks of training	Male
SA258886	90289013110	Training	4 weeks of training	Male
SA258887	90292013110	Training	4 weeks of training	Male
SA258888	90283013110	Training	4 weeks of training	Male
SA258889	90251013110	Training	8 weeks of training or control time	Female
SA258890	90254013110	Training	8 weeks of training or control time	Female
SA258891	90267013110	Training	8 weeks of training or control time	Female
SA258892	90258013110	Training	8 weeks of training or control time	Female
SA258893	90259013110	Training	8 weeks of training or control time	Female
SA258894	90222013110	Training	8 weeks of training or control time	Male
SA258895	90218013110	Training	8 weeks of training or control time	Male
SA258896	90225013110	Training	8 weeks of training or control time	Male
SA258897	90227013110	Training	8 weeks of training or control time	Male
SA258898	90223013110	Training	8 weeks of training or control time	Male

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Showing results 1 to 50 of 50