Summary of Study ST002583

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002583
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Plasma - Targeted Tricarboxylic Acid Cycle
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Mayo Clinic
Department	Internal Medicine
Laboratory	Mayo Clinic Metabolomics Resource Core (MCMRC)
Last Name	Nair
First Name	K. Sreekumaran
Address	200 1st St SW, Rochester, MN 55902
Email	nair@mayo.edu
Phone	(507) 284-2511
Submit Date	2023-04-25
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	GC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA259115	90245013110	Control	8 weeks of training or control time	Female
SA259116	90248013110	Control	8 weeks of training or control time	Female
SA259117	90265013110	Control	8 weeks of training or control time	Female
SA259118	90266013110	Control	8 weeks of training or control time	Female
SA259119	90252013110	Control	8 weeks of training or control time	Female
SA259120	90232013110	Control	8 weeks of training or control time	Male
SA259121	90237013110	Control	8 weeks of training or control time	Male
SA259122	90239013110	Control	8 weeks of training or control time	Male
SA259123	90229013110	Control	8 weeks of training or control time	Male
SA259124	90217013110	Control	8 weeks of training or control time	Male
SA259125	90564013110	Training	1 week of training or control time	Female
SA259126	90567013110	Training	1 week of training or control time	Female
SA259127	90571013110	Training	1 week of training or control time	Female
SA259128	90559013110	Training	1 week of training or control time	Female
SA259129	90560013110	Training	1 week of training or control time	Female
SA259130	90426013110	Training	1 week of training or control time	Male
SA259131	90421013110	Training	1 week of training or control time	Male
SA259132	90430013110	Training	1 week of training or control time	Male
SA259133	90422013110	Training	1 week of training or control time	Male
SA259134	90423013110	Training	1 week of training or control time	Male
SA259135	90587013110	Training	2 weeks of training	Female
SA259136	90585013110	Training	2 weeks of training	Female
SA259137	90578013110	Training	2 weeks of training	Female
SA259138	90581013110	Training	2 weeks of training	Female
SA259139	90576013110	Training	2 weeks of training	Female
SA259140	90439013110	Training	2 weeks of training	Male
SA259141	90444013110	Training	2 weeks of training	Male
SA259142	90441013110	Training	2 weeks of training	Male
SA259143	90450013110	Training	2 weeks of training	Male
SA259144	90449013110	Training	2 weeks of training	Male
SA259145	90416013110	Training	4 weeks of training	Female
SA259146	90420013110	Training	4 weeks of training	Female
SA259147	90412013110	Training	4 weeks of training	Female
SA259148	90410013110	Training	4 weeks of training	Female
SA259149	90406013110	Training	4 weeks of training	Female
SA259150	90292013110	Training	4 weeks of training	Male
SA259151	90280013110	Training	4 weeks of training	Male
SA259152	90281013110	Training	4 weeks of training	Male
SA259153	90289013110	Training	4 weeks of training	Male
SA259154	90283013110	Training	4 weeks of training	Male
SA259155	90267013110	Training	8 weeks of training or control time	Female
SA259156	90259013110	Training	8 weeks of training or control time	Female
SA259157	90258013110	Training	8 weeks of training or control time	Female
SA259158	90251013110	Training	8 weeks of training or control time	Female
SA259159	90254013110	Training	8 weeks of training or control time	Female
SA259160	90227013110	Training	8 weeks of training or control time	Male
SA259161	90218013110	Training	8 weeks of training or control time	Male
SA259162	90222013110	Training	8 weeks of training or control time	Male
SA259163	90223013110	Training	8 weeks of training or control time	Male
SA259164	90225013110	Training	8 weeks of training or control time	Male

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Showing results 1 to 50 of 50