Summary of Study ST002604

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002604
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Kidney - Targeted Amines
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Mayo Clinic
Department	Internal Medicine
Laboratory	Mayo Clinic Metabolomics Resource Core (MCMRC)
Last Name	Nair
First Name	K. Sreekumaran
Address	200 1st St SW, Rochester, MN 55902
Email	nair@mayo.edu
Phone	(507) 284-2511
Submit Date	2023-04-28
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA260271	90266015911	Control	8 weeks of training or control time	Female
SA260272	90245015911	Control	8 weeks of training or control time	Female
SA260273	90248015911	Control	8 weeks of training or control time	Female
SA260274	90265015911	Control	8 weeks of training or control time	Female
SA260275	90252015911	Control	8 weeks of training or control time	Female
SA260276	90239015911	Control	8 weeks of training or control time	Male
SA260277	90237015911	Control	8 weeks of training or control time	Male
SA260278	90229015911	Control	8 weeks of training or control time	Male
SA260279	90232015911	Control	8 weeks of training or control time	Male
SA260280	90217015911	Control	8 weeks of training or control time	Male
SA260281	90559015911	Training	1 week of training or control time	Female
SA260282	90560015911	Training	1 week of training or control time	Female
SA260283	90564015911	Training	1 week of training or control time	Female
SA260284	90567015911	Training	1 week of training or control time	Female
SA260285	90571015911	Training	1 week of training or control time	Female
SA260286	90430015911	Training	1 week of training or control time	Male
SA260287	90421015911	Training	1 week of training or control time	Male
SA260288	90423015911	Training	1 week of training or control time	Male
SA260289	90426015911	Training	1 week of training or control time	Male
SA260290	90422015911	Training	1 week of training or control time	Male
SA260291	90587015911	Training	2 weeks of training	Female
SA260292	90585015911	Training	2 weeks of training	Female
SA260293	90576015911	Training	2 weeks of training	Female
SA260294	90578015911	Training	2 weeks of training	Female
SA260295	90581015911	Training	2 weeks of training	Female
SA260296	90449015911	Training	2 weeks of training	Male
SA260297	90450015911	Training	2 weeks of training	Male
SA260298	90444015911	Training	2 weeks of training	Male
SA260299	90441015911	Training	2 weeks of training	Male
SA260300	90439015911	Training	2 weeks of training	Male
SA260301	90406015911	Training	4 weeks of training	Female
SA260302	90420015911	Training	4 weeks of training	Female
SA260303	90410015911	Training	4 weeks of training	Female
SA260304	90412015911	Training	4 weeks of training	Female
SA260305	90416015911	Training	4 weeks of training	Female
SA260306	90280015911	Training	4 weeks of training	Male
SA260307	90281015911	Training	4 weeks of training	Male
SA260308	90289015911	Training	4 weeks of training	Male
SA260309	90292015911	Training	4 weeks of training	Male
SA260310	90283015911	Training	4 weeks of training	Male
SA260311	90251015911	Training	8 weeks of training or control time	Female
SA260312	90254015911	Training	8 weeks of training or control time	Female
SA260313	90267015911	Training	8 weeks of training or control time	Female
SA260314	90258015911	Training	8 weeks of training or control time	Female
SA260315	90259015911	Training	8 weeks of training or control time	Female
SA260316	90222015911	Training	8 weeks of training or control time	Male
SA260317	90218015911	Training	8 weeks of training or control time	Male
SA260318	90225015911	Training	8 weeks of training or control time	Male
SA260319	90227015911	Training	8 weeks of training or control time	Male
SA260320	90223015911	Training	8 weeks of training or control time	Male

Showing results 1 to 50 of 50

Showing results 1 to 50 of 50