Summary of Study ST002608

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002608
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Lung - Targeted Amines
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Mayo Clinic
Department	Internal Medicine
Laboratory	Mayo Clinic Metabolomics Resource Core (MCMRC)
Last Name	Nair
First Name	K. Sreekumaran
Address	200 1st St SW, Rochester, MN 55902
Email	nair@mayo.edu
Phone	(507) 284-2511
Submit Date	2023-04-28
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA260525	90266016611	Control	8 weeks of training or control time	Female
SA260526	90245016611	Control	8 weeks of training or control time	Female
SA260527	90248016611	Control	8 weeks of training or control time	Female
SA260528	90265016611	Control	8 weeks of training or control time	Female
SA260529	90252016611	Control	8 weeks of training or control time	Female
SA260530	90239016611	Control	8 weeks of training or control time	Male
SA260531	90237016611	Control	8 weeks of training or control time	Male
SA260532	90229016611	Control	8 weeks of training or control time	Male
SA260533	90232016611	Control	8 weeks of training or control time	Male
SA260534	90217016611	Control	8 weeks of training or control time	Male
SA260535	90559016611	Training	1 week of training or control time	Female
SA260536	90560016611	Training	1 week of training or control time	Female
SA260537	90564016611	Training	1 week of training or control time	Female
SA260538	90567016611	Training	1 week of training or control time	Female
SA260539	90571016611	Training	1 week of training or control time	Female
SA260540	90430016611	Training	1 week of training or control time	Male
SA260541	90421016611	Training	1 week of training or control time	Male
SA260542	90423016611	Training	1 week of training or control time	Male
SA260543	90426016611	Training	1 week of training or control time	Male
SA260544	90422016611	Training	1 week of training or control time	Male
SA260545	90587016611	Training	2 weeks of training	Female
SA260546	90585016611	Training	2 weeks of training	Female
SA260547	90576016611	Training	2 weeks of training	Female
SA260548	90578016611	Training	2 weeks of training	Female
SA260549	90581016611	Training	2 weeks of training	Female
SA260550	90449016611	Training	2 weeks of training	Male
SA260551	90450016611	Training	2 weeks of training	Male
SA260552	90444016611	Training	2 weeks of training	Male
SA260553	90441016611	Training	2 weeks of training	Male
SA260554	90439016611	Training	2 weeks of training	Male
SA260555	90406016611	Training	4 weeks of training	Female
SA260556	90420016611	Training	4 weeks of training	Female
SA260557	90410016611	Training	4 weeks of training	Female
SA260558	90412016611	Training	4 weeks of training	Female
SA260559	90416016611	Training	4 weeks of training	Female
SA260560	90280016611	Training	4 weeks of training	Male
SA260561	90281016611	Training	4 weeks of training	Male
SA260562	90289016611	Training	4 weeks of training	Male
SA260563	90292016611	Training	4 weeks of training	Male
SA260564	90283016611	Training	4 weeks of training	Male
SA260565	90251016611	Training	8 weeks of training or control time	Female
SA260566	90254016611	Training	8 weeks of training or control time	Female
SA260567	90267016611	Training	8 weeks of training or control time	Female
SA260568	90258016611	Training	8 weeks of training or control time	Female
SA260569	90259016611	Training	8 weeks of training or control time	Female
SA260570	90222016611	Training	8 weeks of training or control time	Male
SA260571	90218016611	Training	8 weeks of training or control time	Male
SA260572	90225016611	Training	8 weeks of training or control time	Male
SA260573	90227016611	Training	8 weeks of training or control time	Male
SA260574	90223016611	Training	8 weeks of training or control time	Male

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Showing results 1 to 50 of 50