Summary of Study ST002615

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002615
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Liver - Targeted Nucleotides
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Duke University
Department	Duke Molecular Physiology Institute
Laboratory	Metabolomics Core Laboratory
Last Name	Newgard
First Name	Christopher
Address	300 N Duke St, Durham, NC 27701
Email	chris.newgard@duke.edu
Phone	(919) 668-6059
Submit Date	2023-04-28
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA260969	90265016811	Control	8 weeks of training or control time	Female
SA260970	90266016811	Control	8 weeks of training or control time	Female
SA260971	90248016811	Control	8 weeks of training or control time	Female
SA260972	90245016811	Control	8 weeks of training or control time	Female
SA260973	90252016811	Control	8 weeks of training or control time	Female
SA260974	90217016811	Control	8 weeks of training or control time	Male
SA260975	90237016811	Control	8 weeks of training or control time	Male
SA260976	90239016811	Control	8 weeks of training or control time	Male
SA260977	90232016811	Control	8 weeks of training or control time	Male
SA260978	90229016811	Control	8 weeks of training or control time	Male
SA260979	80011826802_2	QC-ExternalStandard	0 hour	-
SA260980	80010816802_3	QC-ExternalStandard	0 hour	-
SA260981	80011826802_1	QC-ExternalStandard	0 hour	-
SA260982	80011826802_4	QC-ExternalStandard	0 hour	-
SA260983	80010816802_4	QC-ExternalStandard	0 hour	-
SA260984	80011826802_3	QC-ExternalStandard	0 hour	-
SA260985	80010816802_1	QC-ExternalStandard	0 hour	-
SA260986	80010816802_2	QC-ExternalStandard	0 hour	-
SA260987	90559016811	Training	1 week of training or control time	Female
SA260988	90571016811	Training	1 week of training or control time	Female
SA260989	90567016811	Training	1 week of training or control time	Female
SA260990	90564016811	Training	1 week of training or control time	Female
SA260991	90560016811	Training	1 week of training or control time	Female
SA260992	90426016811	Training	1 week of training or control time	Male
SA260993	90422016811	Training	1 week of training or control time	Male
SA260994	90423016811	Training	1 week of training or control time	Male
SA260995	90421016811	Training	1 week of training or control time	Male
SA260996	90430016811	Training	1 week of training or control time	Male
SA260997	90587016811	Training	2 weeks of training	Female
SA260998	90576016811	Training	2 weeks of training	Female
SA260999	90585016811	Training	2 weeks of training	Female
SA261000	90581016811	Training	2 weeks of training	Female
SA261001	90578016811	Training	2 weeks of training	Female
SA261002	90444016811	Training	2 weeks of training	Male
SA261003	90441016811	Training	2 weeks of training	Male
SA261004	90439016811	Training	2 weeks of training	Male
SA261005	90449016811	Training	2 weeks of training	Male
SA261006	90450016811	Training	2 weeks of training	Male
SA261007	90410016811	Training	4 weeks of training	Female
SA261008	90406016811	Training	4 weeks of training	Female
SA261009	90416016811	Training	4 weeks of training	Female
SA261010	90412016811	Training	4 weeks of training	Female
SA261011	90420016811	Training	4 weeks of training	Female
SA261012	90289016811	Training	4 weeks of training	Male
SA261013	90292016811	Training	4 weeks of training	Male
SA261014	90280016811	Training	4 weeks of training	Male
SA261015	90283016811	Training	4 weeks of training	Male
SA261016	90281016811	Training	4 weeks of training	Male
SA261017	90259016811	Training	8 weeks of training or control time	Female
SA261018	90251016811	Training	8 weeks of training or control time	Female
SA261019	90267016811	Training	8 weeks of training or control time	Female
SA261020	90254016811	Training	8 weeks of training or control time	Female
SA261021	90258016811	Training	8 weeks of training or control time	Female
SA261022	90227016811	Training	8 weeks of training or control time	Male
SA261023	90222016811	Training	8 weeks of training or control time	Male
SA261024	90223016811	Training	8 weeks of training or control time	Male
SA261025	90225016811	Training	8 weeks of training or control time	Male
SA261026	90218016811	Training	8 weeks of training or control time	Male

Showing results 1 to 58 of 58

Showing results 1 to 58 of 58