Summary of Study ST002617

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002617
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Liver - Targeted Tricarboxylic Acid Cycle
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Mayo Clinic
Department	Internal Medicine
Laboratory	Mayo Clinic Metabolomics Resource Core (MCMRC)
Last Name	Nair
First Name	K. Sreekumaran
Address	200 1st St SW, Rochester, MN 55902
Email	nair@mayo.edu
Phone	(507) 284-2511
Submit Date	2023-04-28
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	GC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA261106	90266016813	Control	8 weeks of training or control time	Female
SA261107	90245016813	Control	8 weeks of training or control time	Female
SA261108	90248016813	Control	8 weeks of training or control time	Female
SA261109	90265016813	Control	8 weeks of training or control time	Female
SA261110	90252016813	Control	8 weeks of training or control time	Female
SA261111	90239016813	Control	8 weeks of training or control time	Male
SA261112	90237016813	Control	8 weeks of training or control time	Male
SA261113	90229016813	Control	8 weeks of training or control time	Male
SA261114	90232016813	Control	8 weeks of training or control time	Male
SA261115	90217016813	Control	8 weeks of training or control time	Male
SA261116	90559016813	Training	1 week of training or control time	Female
SA261117	90560016813	Training	1 week of training or control time	Female
SA261118	90564016813	Training	1 week of training or control time	Female
SA261119	90567016813	Training	1 week of training or control time	Female
SA261120	90571016813	Training	1 week of training or control time	Female
SA261121	90430016813	Training	1 week of training or control time	Male
SA261122	90421016813	Training	1 week of training or control time	Male
SA261123	90423016813	Training	1 week of training or control time	Male
SA261124	90426016813	Training	1 week of training or control time	Male
SA261125	90422016813	Training	1 week of training or control time	Male
SA261126	90587016813	Training	2 weeks of training	Female
SA261127	90585016813	Training	2 weeks of training	Female
SA261128	90576016813	Training	2 weeks of training	Female
SA261129	90578016813	Training	2 weeks of training	Female
SA261130	90581016813	Training	2 weeks of training	Female
SA261131	90449016813	Training	2 weeks of training	Male
SA261132	90450016813	Training	2 weeks of training	Male
SA261133	90444016813	Training	2 weeks of training	Male
SA261134	90441016813	Training	2 weeks of training	Male
SA261135	90439016813	Training	2 weeks of training	Male
SA261136	90406016813	Training	4 weeks of training	Female
SA261137	90420016813	Training	4 weeks of training	Female
SA261138	90410016813	Training	4 weeks of training	Female
SA261139	90412016813	Training	4 weeks of training	Female
SA261140	90416016813	Training	4 weeks of training	Female
SA261141	90280016813	Training	4 weeks of training	Male
SA261142	90281016813	Training	4 weeks of training	Male
SA261143	90289016813	Training	4 weeks of training	Male
SA261144	90292016813	Training	4 weeks of training	Male
SA261145	90283016813	Training	4 weeks of training	Male
SA261146	90251016813	Training	8 weeks of training or control time	Female
SA261147	90254016813	Training	8 weeks of training or control time	Female
SA261148	90267016813	Training	8 weeks of training or control time	Female
SA261149	90258016813	Training	8 weeks of training or control time	Female
SA261150	90259016813	Training	8 weeks of training or control time	Female
SA261151	90222016813	Training	8 weeks of training or control time	Male
SA261152	90218016813	Training	8 weeks of training or control time	Male
SA261153	90225016813	Training	8 weeks of training or control time	Male
SA261154	90227016813	Training	8 weeks of training or control time	Male
SA261155	90223016813	Training	8 weeks of training or control time	Male

Showing results 1 to 50 of 50

Showing results 1 to 50 of 50