Summary of Study ST002622

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002622
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:White Adipose - Targeted Amines
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Mayo Clinic
Department	Internal Medicine
Laboratory	Mayo Clinic Metabolomics Resource Core (MCMRC)
Last Name	Nair
First Name	K. Sreekumaran
Address	200 1st St SW, Rochester, MN 55902
Email	nair@mayo.edu
Phone	(507) 284-2511
Submit Date	2023-04-28
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA261327	90252017014	Control	8 weeks of training or control time	Female
SA261328	90265017014	Control	8 weeks of training or control time	Female
SA261329	90248017014	Control	8 weeks of training or control time	Female
SA261330	90266017014	Control	8 weeks of training or control time	Female
SA261331	90229017014	Control	8 weeks of training or control time	Male
SA261332	90217017014	Control	8 weeks of training or control time	Male
SA261333	90239017014	Control	8 weeks of training or control time	Male
SA261334	90232017014	Control	8 weeks of training or control time	Male
SA261335	90237017014	Control	8 weeks of training or control time	Male
SA261336	90560017014	Training	1 week of training or control time	Female
SA261337	90559017014	Training	1 week of training or control time	Female
SA261338	90567017014	Training	1 week of training or control time	Female
SA261339	90564017014	Training	1 week of training or control time	Female
SA261340	90421017014	Training	1 week of training or control time	Male
SA261341	90430017014	Training	1 week of training or control time	Male
SA261342	90423017014	Training	1 week of training or control time	Male
SA261343	90422017014	Training	1 week of training or control time	Male
SA261344	90426017014	Training	1 week of training or control time	Male
SA261345	90581017014	Training	2 weeks of training	Female
SA261346	90585017014	Training	2 weeks of training	Female
SA261347	90587017014	Training	2 weeks of training	Female
SA261348	90576017014	Training	2 weeks of training	Female
SA261349	90578017014	Training	2 weeks of training	Female
SA261350	90444017014	Training	2 weeks of training	Male
SA261351	90450017014	Training	2 weeks of training	Male
SA261352	90449017014	Training	2 weeks of training	Male
SA261353	90441017014	Training	2 weeks of training	Male
SA261354	90439017014	Training	2 weeks of training	Male
SA261355	90412017014	Training	4 weeks of training	Female
SA261356	90420017014	Training	4 weeks of training	Female
SA261357	90410017014	Training	4 weeks of training	Female
SA261358	90416017014	Training	4 weeks of training	Female
SA261359	90281017014	Training	4 weeks of training	Male
SA261360	90283017014	Training	4 weeks of training	Male
SA261361	90280017014	Training	4 weeks of training	Male
SA261362	90289017014	Training	4 weeks of training	Male
SA261363	90292017014	Training	4 weeks of training	Male
SA261364	90259017014	Training	8 weeks of training or control time	Female
SA261365	90254017014	Training	8 weeks of training or control time	Female
SA261366	90267017014	Training	8 weeks of training or control time	Female
SA261367	90218017014	Training	8 weeks of training or control time	Male
SA261368	90222017014	Training	8 weeks of training or control time	Male
SA261369	90223017014	Training	8 weeks of training or control time	Male
SA261370	90225017014	Training	8 weeks of training or control time	Male

Showing results 1 to 44 of 44

Showing results 1 to 44 of 44