Summary of Study ST002624

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002624
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:White Adipose - Targeted Keto Acids
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Duke University
Department	Duke Molecular Physiology Institute
Laboratory	Metabolomics Core Laboratory
Last Name	Newgard
First Name	Christopher
Address	300 N Duke St, Durham, NC 27701
Email	chris.newgard@duke.edu
Phone	(919) 668-6059
Submit Date	2023-04-25
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA261450	90266017012	Control	8 weeks of training or control time	Female
SA261451	90248017012	Control	8 weeks of training or control time	Female
SA261452	90252017012	Control	8 weeks of training or control time	Female
SA261453	90265017012	Control	8 weeks of training or control time	Female
SA261454	90245017012	Control	8 weeks of training or control time	Female
SA261455	90237017012	Control	8 weeks of training or control time	Male
SA261456	90229017012	Control	8 weeks of training or control time	Male
SA261457	90232017012	Control	8 weeks of training or control time	Male
SA261458	90217017012	Control	8 weeks of training or control time	Male
SA261459	90239017012	Control	8 weeks of training or control time	Male
SA261460	80012817002_2	QC-ExternalStandard	0 hour	-
SA261461	80013827002_2	QC-ExternalStandard	0 hour	-
SA261462	80013827002_3	QC-ExternalStandard	0 hour	-
SA261463	80012817002_3	QC-ExternalStandard	0 hour	-
SA261464	80013827002_1	QC-ExternalStandard	0 hour	-
SA261465	80012817002_1	QC-ExternalStandard	0 hour	-
SA261466	80013827002_4	QC-ExternalStandard	0 hour	-
SA261467	80012817002_4	QC-ExternalStandard	0 hour	-
SA261468	90564017012	Training	1 week of training or control time	Female
SA261469	90567017012	Training	1 week of training or control time	Female
SA261470	90560017012	Training	1 week of training or control time	Female
SA261471	90571017012	Training	1 week of training or control time	Female
SA261472	90559017012	Training	1 week of training or control time	Female
SA261473	90430017012	Training	1 week of training or control time	Male
SA261474	90423017012	Training	1 week of training or control time	Male
SA261475	90426017012	Training	1 week of training or control time	Male
SA261476	90421017012	Training	1 week of training or control time	Male
SA261477	90422017012	Training	1 week of training or control time	Male
SA261478	90578017012	Training	2 weeks of training	Female
SA261479	90576017012	Training	2 weeks of training	Female
SA261480	90585017012	Training	2 weeks of training	Female
SA261481	90587017012	Training	2 weeks of training	Female
SA261482	90581017012	Training	2 weeks of training	Female
SA261483	90439017012	Training	2 weeks of training	Male
SA261484	90449017012	Training	2 weeks of training	Male
SA261485	90444017012	Training	2 weeks of training	Male
SA261486	90450017012	Training	2 weeks of training	Male
SA261487	90441017012	Training	2 weeks of training	Male
SA261488	90420017012	Training	4 weeks of training	Female
SA261489	90410017012	Training	4 weeks of training	Female
SA261490	90416017012	Training	4 weeks of training	Female
SA261491	90412017012	Training	4 weeks of training	Female
SA261492	90281017012	Training	4 weeks of training	Male
SA261493	90289017012	Training	4 weeks of training	Male
SA261494	90280017012	Training	4 weeks of training	Male
SA261495	90283017012	Training	4 weeks of training	Male
SA261496	90292017012	Training	4 weeks of training	Male
SA261497	90254017012	Training	8 weeks of training or control time	Female
SA261498	90251017012	Training	8 weeks of training or control time	Female
SA261499	90267017012	Training	8 weeks of training or control time	Female
SA261500	90259017012	Training	8 weeks of training or control time	Female
SA261501	90258017012	Training	8 weeks of training or control time	Female
SA261502	90225017012	Training	8 weeks of training or control time	Male
SA261503	90222017012	Training	8 weeks of training or control time	Male
SA261504	90227017012	Training	8 weeks of training or control time	Male
SA261505	90218017012	Training	8 weeks of training or control time	Male
SA261506	90223017012	Training	8 weeks of training or control time	Male

Showing results 1 to 57 of 57

Showing results 1 to 57 of 57