Summary of Study ST002628

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002628
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Plasma - Untargeted HILIC-Positive
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Broad Institute of MIT and Harvard
Department	Metabolomics Platform
Laboratory	Clish
Last Name	Clish
First Name	Clary
Address	415 Main St, Cambridge, MA 02142
Email	clary@broadinstitute.org
Phone	(617) 714-7654
Submit Date	2023-04-28
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex	Tissue
SA261688	90245013104	Control	8 weeks of training or control time	Female	Rat Plasma
SA261689	90248013104	Control	8 weeks of training or control time	Female	Rat Plasma
SA261690	90252013104	Control	8 weeks of training or control time	Female	Rat Plasma
SA261691	90266013104	Control	8 weeks of training or control time	Female	Rat Plasma
SA261692	90265013104	Control	8 weeks of training or control time	Female	Rat Plasma
SA261693	90237013104	Control	8 weeks of training or control time	Male	Rat Plasma
SA261694	90229013104	Control	8 weeks of training or control time	Male	Rat Plasma
SA261695	90239013104	Control	8 weeks of training or control time	Male	Rat Plasma
SA261696	90217013104	Control	8 weeks of training or control time	Male	Rat Plasma
SA261697	90232013104	Control	8 weeks of training or control time	Male	Rat Plasma
SA261698	QC_PREFA03	QC-DriftCorrection	0 hour	-	-
SA261699	QC_PREFA01	QC-DriftCorrection	0 hour	-	-
SA261700	QC_PREFA02	QC-DriftCorrection	0 hour	-	-
SA261701	QC_PREFA04	QC-DriftCorrection	0 hour	-	-
SA261702	QC_PREFB02	QC-Pooled	0 hour	-	-
SA261703	QC_PREFB04	QC-Pooled	0 hour	-	-
SA261704	QC_PREFB01	QC-Pooled	0 hour	-	-
SA261705	QC_PREFB03	QC-Pooled	0 hour	-	-
SA261706	QC_Sed02	QC-Reference	0 hour	-	-
SA261707	QC_IPE01	QC-Reference	0 hour	-	-
SA261708	QC_IPE04	QC-Reference	0 hour	-	-
SA261709	QC_IPE03	QC-Reference	0 hour	-	-
SA261710	QC_Sed01	QC-Reference	0 hour	-	-
SA261711	QC_Sed04	QC-Reference	0 hour	-	-
SA261712	QC_IPE02	QC-Reference	0 hour	-	-
SA261713	QC_Sed03	QC-Reference	0 hour	-	-
SA261714	90564013104	Training	1 week of training or control time	Female	Rat Plasma
SA261715	90567013104	Training	1 week of training or control time	Female	Rat Plasma
SA261716	90559013104	Training	1 week of training or control time	Female	Rat Plasma
SA261717	90560013104	Training	1 week of training or control time	Female	Rat Plasma
SA261718	90571013104	Training	1 week of training or control time	Female	Rat Plasma
SA261719	90423013104	Training	1 week of training or control time	Male	Rat Plasma
SA261720	90426013104	Training	1 week of training or control time	Male	Rat Plasma
SA261721	90430013104	Training	1 week of training or control time	Male	Rat Plasma
SA261722	90421013104	Training	1 week of training or control time	Male	Rat Plasma
SA261723	90422013104	Training	1 week of training or control time	Male	Rat Plasma
SA261724	90578013104	Training	2 weeks of training	Female	Rat Plasma
SA261725	90587013104	Training	2 weeks of training	Female	Rat Plasma
SA261726	90581013104	Training	2 weeks of training	Female	Rat Plasma
SA261727	90585013104	Training	2 weeks of training	Female	Rat Plasma
SA261728	90576013104	Training	2 weeks of training	Female	Rat Plasma
SA261729	90449013104	Training	2 weeks of training	Male	Rat Plasma
SA261730	90444013104	Training	2 weeks of training	Male	Rat Plasma
SA261731	90439013104	Training	2 weeks of training	Male	Rat Plasma
SA261732	90450013104	Training	2 weeks of training	Male	Rat Plasma
SA261733	90441013104	Training	2 weeks of training	Male	Rat Plasma
SA261734	90406013104	Training	4 weeks of training	Female	Rat Plasma
SA261735	90420013104	Training	4 weeks of training	Female	Rat Plasma
SA261736	90410013104	Training	4 weeks of training	Female	Rat Plasma
SA261737	90412013104	Training	4 weeks of training	Female	Rat Plasma
SA261738	90416013104	Training	4 weeks of training	Female	Rat Plasma
SA261739	90280013104	Training	4 weeks of training	Male	Rat Plasma
SA261740	90281013104	Training	4 weeks of training	Male	Rat Plasma
SA261741	90289013104	Training	4 weeks of training	Male	Rat Plasma
SA261742	90292013104	Training	4 weeks of training	Male	Rat Plasma
SA261743	90283013104	Training	4 weeks of training	Male	Rat Plasma
SA261744	90251013104	Training	8 weeks of training or control time	Female	Rat Plasma
SA261745	90254013104	Training	8 weeks of training or control time	Female	Rat Plasma
SA261746	90267013104	Training	8 weeks of training or control time	Female	Rat Plasma
SA261747	90258013104	Training	8 weeks of training or control time	Female	Rat Plasma
SA261748	90259013104	Training	8 weeks of training or control time	Female	Rat Plasma
SA261749	90222013104	Training	8 weeks of training or control time	Male	Rat Plasma
SA261750	90218013104	Training	8 weeks of training or control time	Male	Rat Plasma
SA261751	90225013104	Training	8 weeks of training or control time	Male	Rat Plasma
SA261752	90227013104	Training	8 weeks of training or control time	Male	Rat Plasma
SA261753	90223013104	Training	8 weeks of training or control time	Male	Rat Plasma

Showing results 1 to 66 of 66

Showing results 1 to 66 of 66